protein

Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His)

HY-P700890

20 μg;50 μg;100 μg

205;375;600 USD

Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

205;375;600 USD

Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Latent TGF beta 3/Latent TGFB3 Protein, Human (HEK293, His) is 389 a.a., with molecular weight of 46-50 kDa & 55-60 kDa, respectively.

Human

Latent Transforming growth factor beta-3 (TGF-beta-3) proprotein serves as the precursor for both the Latency-associated peptide (LAP) and the active TGF-beta-3 chains, acting as the regulatory and functional subunits, respectively. It plays a vital role in maintaining the latent state of TGF-beta-3 within the extracellular matrix. Through non-covalent association with TGF-beta-3, Latent TGF-beta-3 actively regulates the activation process by interacting with key 'milieu molecules' such as LTBP1 and LRRC32/GARP. These interactions contribute to the controlled activation of TGF-beta-3, with LTBP1 and LRRC32/GARP acting as crucial components in this regulatory mechanism. Additionally, interaction with integrins induces structural changes in the Latency-associated peptide chain, leading to the subsequent release of active TGF-beta-3. This sophisticated molecular interplay underscores the pivotal role of Latent TGF-beta-3 in orchestrating the regulated activation of TGF-beta-3 in various physiological contexts.

TGFB3; ARVD; TGF-beta3; TGF-β; TGFβ3; TGFβ

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.