protein

IL-23R Protein, Cynomolgus (HEK293, C-His)

HY-P700889

20 μg;50 μg;100 μg

170;325;520 USD

IL-23R Protein, Cynomolgus (HEK293, C-His)

proteins

HEK293

20 μg;50 μg;100 μg

170;325;520 USD

IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Cynomolgus (HEK293, C-His) is the recombinant cynomolgus-derived IL-23R protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-23R Protein, Cynomolgus (HEK293, C-His) is 330 a.a., with molecular weight of 60-80 kDa.

Cynomolgus

The IL-23R Protein forms the interleukin-23 receptor in association with IL12RB1. Acting as a binding site for IL23, this receptor mediates stimulation in T-cells, NK cells, and possibly certain macrophage/myeloid cells, likely through the activation of the Jak-Stat signaling cascade. IL-23R plays a crucial role in both innate and adaptive immunity and may contribute to the acute response to infection in peripheral tissues. Additionally, IL-23R has been implicated in autoimmune inflammatory diseases and is thought to be significant in tumorigenesis. Operating as a heterodimer with IL12RB1, the IL-23R complex, when exposed to IL23, forms the functional IL23 receptor. Furthermore, IL-23R interacts with JAK2 and, in the presence of IL23, associates with STAT3, contributing to downstream signaling processes (By similarity).

IBD17; IL-23 R; IL-23 receptor

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.