protein

MRC2 Protein, Human (HEK293, His)

HY-P700875

20 μg;50 μg;100 μg

220;400;640 USD

MRC2 Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

220;400;640 USD

The MRC2 protein may function as an endocytic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands via clathrin-mediated endocytosis and releases them in endosomes. MRC2 Protein, Human (HEK293, His) is the recombinant human-derived MRC2 protein, expressed by HEK293 , with C-His labeled tag. The total length of MRC2 Protein, Human (HEK293, His) is 500 a.a., with molecular weight of 65-75 kDa.

Human

The MRC2 protein is implicated in potentially playing a role as an endocytotic lectin receptor with calcium-dependent lectin activity. It functions by internalizing glycosylated ligands from the extracellular space, releasing them in an endosomal compartment through clathrin-mediated endocytosis. MRC2 may be involved in the plasminogen activation system, controlling the extracellular levels of PLAUR/PLAU and thus regulating protease activity at the cell surface. Additionally, it is suggested to contribute to the cellular uptake, remodeling, and degradation of extracellular collagen matrices, potentially influencing collagen turnover during cancer progression and other chronic tissue destructive diseases. MRC2's involvement in the remodeling of the extracellular matrix is proposed to collaborate with matrix metalloproteinases (MMPs). It interacts with the C-terminal region of type I collagen/COL1A1, forms a tri-molecular complex with PLAUR/UPAR and PLAU/pro-UPA, and directly interacts with collagen V, highlighting its versatile role in cellular processes related to extracellular matrix dynamics.

C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein (UPAR-associated protein; Urokinase receptor-associated protein)

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.