protein

Integrin alpha M beta 2 Protein, Human (HEK293, His)

HY-P700759

20 μg;50 μg;100 μg

145;320;540 USD

Integrin alpha M beta 2 Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

145;320;540 USD

Integrin α M β 2 (ITGAM/ITGB2) mediates adhesion of monocytes and granulocytes and promotes uptake of complement-coated particles and pathogens. As a receptor for iC3b and fibrinogen, it regulates neutrophil migration, contributes to CD177-PRTN3-mediated activation, and may influence phagocytosis-induced apoptosis. Integrin alpha M beta 2 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Integrin alpha M beta 2 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha M beta 2 Protein, Human (HEK293, His), has molecular weight of 140-160 kDa (ITGAM) & 90-100 kDa (ITGB2), respectively.

Human

Integrin alpha M beta 2, also known as ITGAM/ITGB2, plays a crucial role in mediating adhesive interactions of monocytes, macrophages, and granulocytes, facilitating the uptake of complement-coated particles and pathogens. It serves as the receptor for the iC3b fragment of the third complement component and likely recognizes the R-G-D peptide in C3b. Additionally, this integrin complex acts as a receptor for fibrinogen, factor X, and ICAM1, recognizing specific peptides within fibrinogen gamma chain. ITGAM/ITGB2 regulates neutrophil migration and is essential for CD177-PRTN3-mediated activation of TNF-primed neutrophils. It may also contribute to the regulation of phagocytosis-induced apoptosis in extravasated neutrophils and play a role in mast cell development. Furthermore, in conjunction with TYROBP/DAP12, it is required in microglia to control the production of superoxide ions, promoting neuronal apoptosis during brain development. The interaction with various proteins, including JAM3 and THBD, highlights the multifaceted functions of Integrin alpha M beta 2 in cellular processes. Additionally, its association with complement factor H/CFH facilitates neutrophil adhesion to pathogens, contributing to pathogen clearance.

αMβ2; ITGAM ITGAM; ITGB2; Mac-1; complement receptor-3 (CR3)

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.