Integrin alpha L beta 2 Protein, Mouse (HEK293, His) | MedChem Express LLC HY-P700758 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

Integrin alpha L beta 2 Protein, Mouse (HEK293, His)

catalog :

HY-P700758

quantity :

20 μg;50 μg

price :

230;500 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P700758

Product Name :

Integrin alpha L beta 2 Protein, Mouse (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

20 μg;50 μg

List Price :

230;500 USD

Product Description :

The integrin alpha L beta 2 protein is a receptor for ICAM1, ICAM2, ICAM3, ICAM4, and F11R and is involved in immune phenomena, including leukocyte-endothelial cell interactions, cytotoxic T cell killing, and antibody-dependent killing. It contributes to natural killer cell cytotoxicity and leukocyte adhesion and migration. Integrin alpha L beta 2 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha L beta 2 protein, expressed by HEK293 , with C-His labeled tag. Integrin alpha L beta 2 Protein, Mouse (HEK293, His), has molecular weight of 160-180 kDa (ITGAL) & 90-105 kDa (ITGB2), respectively.

SpeciesSummary :

Mouse

Background :

Integrin alpha L beta 2 (ITGAL/ITGB2) serves as a receptor for ICAM1, ICAM2, ICAM3, and ICAM4, and also interacts with the secreted form of ubiquitin-like protein ISG15 through its ITGAL subunit. Additionally, it functions as a receptor for F11R and plays a role in immune processes such as leukocyte-endothelial cell interaction, cytotoxic T-cell-mediated killing, and antibody-dependent killing by granulocytes and monocytes. ITGAL/ITGB2 contributes to natural killer cell cytotoxicity, as well as leukocyte adhesion and transmigration, involving T-cells and neutrophils. Its significance extends to the generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Furthermore, in association with ICAM3, ITGAL/ITGB2 contributes to apoptotic neutrophil phagocytosis by macrophages. The heterodimeric structure comprises an alpha subunit (ITGAL) and a beta subunit (ITGB2), with the alpha subunit interacting with THBD. This multifaceted functionality underscores the diverse roles of Integrin alpha L beta 2 in various immune and cellular processes.

ALTnames :

αLβ2; ITGAL ITGAL; ITGB2

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Buffer :

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage