Integrin alpha 2 beta 1 Protein, Mouse (HEK293, His) | MedChem Express LLC HY-P700753 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

Integrin alpha 2 beta 1 Protein, Mouse (HEK293, His)

catalog :

HY-P700753

quantity :

20 μg;50 μg

price :

140;310 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P700753

Product Name :

Integrin alpha 2 beta 1 Protein, Mouse (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

20 μg;50 μg

List Price :

140;310 USD

Product Description :

Integrin α-2/β-1 is a key collagen receptor that focuses platelet and cell adhesion to collagen and regulates collagen and collagenase gene expression.In addition to its collagen-related functions, it contributes to force generation, extracellular matrix organization, and recognition of laminin, collagen C propeptide, and E-cadherin.Integrin alpha 2 beta 1 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha 2 beta 1 protein, expressed by HEK293 , with C-His labeled tag.Integrin alpha 2 beta 1 Protein.

SpeciesSummary :

Mouse

Background :

The Integrin alpha-2/beta-1 protein serves as a pivotal collagen receptor, playing a central role in platelet and cell adhesion to collagens, as well as in the modulation of collagen and collagenase gene expression. Beyond its collagen-related functions, it contributes to force generation and the organization of newly synthesized extracellular matrix. Moreover, Integrin alpha-2/beta-1 acts as a versatile receptor, recognizing laminins, collagen C-propeptides, and E-cadherin. In embryogenesis, mice with a null mutation in the alpha-2 subunit face early mortality, underscoring the critical role of Integrin alpha-2/beta-1 in developmental processes. Structurally, it forms a heterodimeric complex, with the alpha-2 subunit associating with beta-1. The protein further interacts with HPS5 and RAB21, revealing additional dimensions to its regulatory and signaling functions. Overall, Integrin alpha-2/beta-1 emerges as a key player in mediating cellular interactions with the extracellular matrix and influencing essential developmental processes.

ALTnames :

α2β1; ITGA2 ITGA2; ITGB1;

Purity :

Greater than 95% as determined by reducing Tris-Bis PAGE.

Buffer :

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage