protein

G-CSFR/CD114 Protein, Mouse (HEK293, His)

HY-P700725

20 μg;50 μg

150;280 USD

G-CSFR/CD114 Protein, Mouse (HEK293, His)

proteins

HEK293

20 μg;50 μg

150;280 USD

The G-CSFR/CD114 protein serves as a receptor for granulocyte colony-stimulating factor (CSF3) and plays a key role in granulocyte development and function. As a homodimer, it binds two CSF3 molecules and transduces signals. G-CSFR/CD114 Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-His labeled tag. The total length of G-CSFR/CD114 Protein, Mouse (HEK293, His) is 601 a.a., with molecular weight of 90-110 kDa.

Mouse

G-CSFR/CD114 Protein acts as the receptor for granulocyte colony-stimulating factor (CSF3) and may additionally play a role in certain adhesion or recognition events at the cell surface. Existing as a homodimer, the receptor binds two CSF3 molecules, facilitating the transduction of signals related to granulocyte development and function. Moreover, G-CSFR/CD114 interacts with CEACAM1, leading to the down-regulation of the CSF3R-STAT3 pathway. This process involves the recruitment of PTPN6, which subsequently dephosphorylates CSF3R, revealing a regulatory aspect of G-CSFR/CD114 in modulating signaling pathways associated with granulocyte colony-stimulating factor responses. These interactions highlight the intricate regulatory roles of G-CSFR/CD114 in cellular processes related to immune responses and hematopoiesis.

G-CSF-R; G-CSF R; CD114; G CSF R; CSF3R; Csfgr; GCSFR

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.