protein

TPBG/5T4 Protein, Cynomolgus (HEK293, His)

HY-P70071

10 μg;50 μg

105;300 USD

TPBG/5T4 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

10 μg;50 μg

105;300 USD

TPBG/5T4 protein blocks Wnt3a-dependent LRP6 internalization by indirectly interacting with LRP6, thereby potentially inhibiting Wnt/β-catenin signaling. This unique mechanism suggests that TPBG/5T4 plays a crucial role in regulating the Wnt/β-catenin pathway by disrupting LRP6 internalization and affecting downstream signaling. TPBG/5T4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TPBG/5T4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TPBG/5T4 Protein, Cynomolgus (HEK293, His) is 321 a.a., with molecular weight of 55-80 kDa.

Cynomolgus

The TPBG/5T4 Protein emerges as a potential inhibitor of Wnt/beta-catenin signaling, operating through an indirect interaction with LRP6 and the blocking of Wnt3a-dependent LRP6 internalization. This distinctive mechanism suggests that TPBG/5T4 plays a crucial role in regulating the Wnt/beta-catenin pathway by disrupting the internalization process of LRP6, thereby influencing downstream signaling events. This insight into TPBG/5T4's function underscores its significance in modulating the intricate molecular dynamics associated with Wnt/beta-catenin signaling, offering a potential avenue for therapeutic exploration in the context of cellular regulatory processes.

rCynTrophoblast glycoprotein/5T4, His; TPBG; 5T4 Protein, Human; 5T4AG Protein, Human; M6P1 Protein, Human; WAIF1 Protein, Human

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.