ENPP-1 Protein, Mouse (HEK293, His) | MedChem Express LLC HY-P700709 product information

product summary

company name :

MedChem Express LLC

product type :

protein

product name :

ENPP-1 Protein, Mouse (HEK293, His)

catalog :

HY-P700709

quantity :

20 μg;50 μg;100 μg

price :

160;350;595 USD

more info or order :

MedChem Express LLC product webpage

product information

Catalog Number :

HY-P700709

Product Name :

ENPP-1 Protein, Mouse (HEK293, His)

Product Type :

proteins

Host Species :

HEK293

Size :

20 μg;50 μg;100 μg

List Price :

160;350;595 USD

Product Description :

ENPP-1 is a nucleotide pyrophosphatase that critically regulates bone mineralization and soft tissue calcification through the production of diphosphate (PPi).This PPi inhibits the growth of hydroxyapatite crystals and prevents unwanted mineralization.ENPP-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ENPP-1 protein, expressed by HEK293 , with C-His labeled tag.

SpeciesSummary :

Mouse

Background :

The ENPP-1 protein, a nucleotide pyrophosphatase, plays a crucial role in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. It generates diphosphate (PPi), which inhibits the mineralization of bone and calcification of soft tissues by binding to nascent hydroxyapatite crystals, preventing their further growth. ENPP-1 exhibits preferential hydrolysis of ATP but can also hydrolyze other nucleoside 5' triphosphates and diadenosine polyphosphates. Additionally, it participates in the regulation of nucleotide sugars in the endoplasmic reticulum and Golgi, impacting purinergic signaling. The protein inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling, although the direct or indirect nature of hedgehog inhibition remains unclear. ENPP-1 is implicated in modulating insulin sensitivity and melanogenesis. Notably, it can hydrolyze 2',3'-cGAMP, a second messenger activating TMEM173/STING and triggering type-I interferon production, though the precise role of this hydrolysis in the extracellular space is not fully understood. However, ENPP-1 is unable to hydrolyze the 2',3'-cGAMP linkage isomer 3',3'-cGAMP.

ALTnames :

E-NPP 1; NPPase; ENPP1; NPPS; PC1; PDNP1; Ly-41 Antigen; M6S1; M6S1NPP1; NPP1; PCA1; PCA1ARHR2

Purity :

Greater than 95% as determined by Tris-Bis PAGE.

Buffer :

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Storage :

Room temperature in continental US; may vary elsewhere.

more info or order :

MedChem Express LLC product webpage