protein

BMP-2 Protein, Human/Mouse/Rat (Tag Free)

HY-P7006B

2 μg;10 μg;50 μg;100 μg;250 μg;500 μg;1 mg

35;75;210;350;800;1300;2100 USD

BMP-2 Protein, Human/Mouse/Rat (Tag Free)

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;250 μg;500 μg;1 mg

35;75;210;350;800;1300;2100 USD

Bone morphogenetic protein 2 (BMP-2) is a pleiotropic ligand protein belonging to TNFβ family, and is involved in key embryonic development of vascular and valvular homeostasis. BMP-2 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to regulate various types of calcification, including atherosclerosis, chronic kidney disease, diabetes, and valve calcification [1] . BMP-2 is overexpressed by myofibroblast and preosteoblast in the calcified area of human calcified valve, which are densely infiltrated by B lymphocytes and T lymphocytes [2] . BMP-2 is the junction between atherosclerotic vascular calcification and normal bone formation mechanism [3] . BMP-2 Protein, Human/Mouse/Rat is 104 a.a. (Q283-R396), expressed in E. coli.

Rat;Mouse;Human

Bone Morphogenetic Protein 2 (BMP-2) is a ligand protein with pleiotropic, belongs to TNFβ family. BMP-2 formats BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development [1] . BMP-2/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms [4] . BMP-2 is widely found in different animals, while the sequence in human is similar to Rat (91.86%), and mouse (92.13%). BMPs exhibits critical contributions to the pathophysiology of atherosclerosis, pulmonary vascular disease, and vascular and valvular calcification [1] . BMP-2 binds different receptor, such as type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A), to regulate various calcification type including Atherosclerosis, Chronic Kidney Disease, Diabetes, Valvular Calcification [1] . BMP-2 promotes monocyte infiltration and inflammation of atherosclerotic legions [5] . It is linked to increased plaque formation via pro-inflammatory and pro-atherogenic effects, promoting oxidative stress, endothelial dysfunction and osteogenic differentiation [6] . BMP-2 is overexpressed in ossified regions of human calcified valves by myofibroblasts and pre-osteoblasts in areas densely infiltrated with B- and T-lymphocytes [2] . And it serves as the linkers between atherosclerotic vascular calcification with mechanisms of normal bone formation [3] . BMP-2 induces angiogenesis, endothelial cells (ECs) proliferation, and migration [7] . And BMP-2 also enhances the expression of the osteoblast and chondrocyte master transcriptional regulator RUNX2 to promote the mineralization of cultured human coronary vascular SMCs in a manner that was dependent on oxidative stress and endoplasmic reticulum (ER) stress [8] .

rHuBMP-2; BMP2A; BMP-2A; BMP2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from sterile 50 mM Tris-HCL, 200 mM NaCL, 500 mM arginine, pH 8.0 or 50 mM Tris-HCL, 200 mM NaCl, 500 mM arginine, pH 8.0, 5% trehalose or 0.1% TFA, 30% Acetonitrile, pH 2.5 or pH 2.4.

Room temperature in continental US; may vary elsewhere.