protein

Animal-Free BMP-2 Protein, Human/Mouse/Rat (His)

HY-P7006AF

10 μg;50 μg

150;480 USD

Animal-Free BMP-2 Protein, Human/Mouse/Rat (His)

proteins

E. coli

10 μg;50 μg

150;480 USD

BMP-2 protein is an important member of the TGF-β superfamily and is critical in cardiogenesis, neurogenesis, and osteogenesis, inducing cartilage and bone formation. It initiates canonical BMP signaling by binding to BMPR1A and BMPR2, triggering BMPR2 phosphorylation and SMAD1/5/8 activation for gene transcription regulation. Animal-Free BMP-2 Protein, Human/Mouse/Rat (His) is the recombinant human-derived animal-Free BMP-2 protein, expressed by E. coli , with C-His labeled tag.This product is for cell culture use only.

Human

BMP-2 Protein, a vital member of the TGF-beta superfamily, plays essential roles in diverse developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. It induces cartilage and bone formation and initiates the canonical BMP signaling cascade by binding to type I receptor BMPR1A and type II receptor BMPR2. This complex formation triggers BMPR2 phosphorylation, activating BMPR1A, which, in turn, phosphorylates SMAD1/5/8 to modulate gene transcription. BMP-2 also engages non-canonical pathways, such as the ERK/MAP kinase signaling cascade, influencing osteoblast differentiation. Additionally, it stimulates myoblast differentiation into osteoblasts through the EIF2AK3-EIF2A-ATF4 pathway. Acting as a positive regulator of odontoblast differentiation, BMP-2 forms homodimers and interacts with various proteins, including SOSTDC1, GREM2, RGMA, RGMB, RGMC, ASPN, FBN1, FBN2, SCUBE3, TNFAIP6, and ERFE. Its intricate interactions highlight its versatile regulatory roles in multiple cellular processes.

Endogenous Mediator (LEM); Mononuclear Cell Factor (MCF)

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5, trehalose.

Room temperature in continental US; may vary elsewhere.