protein

CD300a/LMIR1 Protein, Cynomolgus (HEK293, His)

HY-P700674

20 μg;50 μg;100 μg

240;455;720 USD

CD300a/LMIR1 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

240;455;720 USD

CD300a/LMIR1 Protein, an inhibitory receptor, potentially diminishes cytolytic activity in NK cells and suppresses mast cell degranulation. It serves as a negative regulator in MYD88-mediated TLR signaling, activating PTPN6 but not TRIF. Upon tyrosine phosphorylation, CD300a/LMIR1 engages with PTN6/SHP-1, PTPN11/SHP-2, and INPP5D, showcasing its multifaceted involvement in immune regulation and cellular responses. CD300a/LMIR1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD300a/LMIR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD300a/LMIR1 Protein, Cynomolgus (HEK293, His) is 161 a.a., with molecular weight of 45-50 kDa.

Cynomolgus

CD300a/LMIR1, an inhibitory receptor, potentially plays a role in diminishing cytolytic activity in natural killer (NK) cells and suppressing mast cell degranulation. Additionally, it acts as a negative regulator in Toll-like receptor (TLR) signaling mediated by MYD88, although not TRIF, by activating PTPN6. Upon tyrosine phosphorylation, CD300a/LMIR1 engages with PTN6/SHP-1 and PTPN11/SHP-2, as well as INPP5D, illustrating its multifaceted involvement in immune regulation and cellular responses.

IGSF12; IRp60; CLM-8; IRC1; CD300a; CLM8; LMIR1; MAIR-I; Mcipr1; NKRL; Pigr4

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.