protein

ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His)

HY-P700655

20 μg;50 μg;100 μg

160;320;550 USD

ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

160;320;550 USD

ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is 243 a.a., with molecular weight of 35-40 kDa.

Cynomolgus

ANGPTL4/Angiopoietin-related 4 Protein assumes a pivotal role in the intricate regulation of lipid metabolism by mediating the inactivation of lipoprotein lipase (LPL), thereby contributing to the control of triglyceride clearance from the bloodstream. Beyond its involvement in lipid metabolism, ANGPTL4 may also play a crucial part in regulating glucose homeostasis and insulin sensitivity. Moreover, it exerts inhibitory effects on endothelial cells by impeding proliferation, migration, and tubule formation, ultimately reducing vascular leakage. In vitro studies demonstrate that ANGPTL4, when expressed heterologously, hampers endothelial cell adhesion to the extracellular matrix (ECM), inhibits the reorganization of the actin cytoskeleton, and disrupts the formation of actin stress fibers and focal adhesions. Additionally, ANGPTL4's cleaved form exhibits higher activity in LPL inactivation compared to the uncleaved protein, further emphasizing its multifaceted role in lipid homeostasis and endothelial cell function. Depending on the context, ANGPTL4 may also modulate tumor-related angiogenesis, underscoring its contextual influence on diverse physiological processes.

ANGPTL4; ARP4; FIAF; HFARP; Angiopoietin like 4; NGPTL2; NL2; PGAR; pp1158; ANG-3; ANG4; AGP4; ANG3; ANG-3; ANG-4;

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.