protein

RIPK2 Protein, Human (P. pastoris, His)

HY-P700624

20 μg;50 μg;100 μg

170;325;520 USD

RIPK2 Protein, Human (P. pastoris, His)

proteins

P. pastoris

20 μg;50 μg;100 μg

170;325;520 USD

RIPK2 is a multifunctional serine/threonine/tyrosine protein kinase that coordinates innate and adaptive immune responses. It is activated by bacterial peptidoglycan to form filaments in the NOD1 and NOD2 pathways, undergoing autophosphorylation and polyubiquitination. RIPK2 Protein, Human (P. pastoris, His) is the recombinant human-derived RIPK2 protein, expressed by P. pastoris , with C-6*His, C-6*His labeled tag. The total length of RIPK2 Protein, Human (P. pastoris, His) is 540 a.a., with molecular weight of 66 kDa.

Human

RIPK2, a serine/threonine/tyrosine-protein kinase, plays a pivotal role in orchestrating innate and adaptive immune responses. As a key effector in NOD1 and NOD2 signaling pathways, RIPK2 forms filaments upon activation by bacterial peptidoglycans, recruited via CARD-CARD domains. Autophosphorylation and polyubiquitination follow, involving 'Lys-63'-linked ubiquitin chains by XIAP, BIRC2, and BIRC3, as well as 'Met-1'-linked polyubiquitination by the LUBAC complex. This transforms RIPK2 into a scaffolding protein, recruiting downstream effectors. 'Lys-63'-linked polyubiquitin chains on RIPK2 facilitate the recruitment of IKBKG/NEMO, initiating the activation of IKBKB/IKKB and subsequent NF-kappa-B release from inhibitors. While the kinase activity is dispensable for NOD1 and NOD2 pathways, RIPK2 contributes to tyrosine phosphorylation of ARHGEF2, activating NF-kappa-B through NOD2. Additionally, in adaptive immunity, RIPK2 promotes BCL10 phosphorylation during T-cell receptor engagement, and participates in RHOA inactivation in response to NGFR signaling. This multifaceted kinase stands as a crucial mediator in diverse immune processes.

receptor-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD3; CARDIAK; RICK; RIP2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor interacting protein 2; receptor-interacting protein 2; RIP-like-interacting CLARP kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; CCK; GIG30;

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Room temperature in continental US; may vary elsewhere.