protein

SHP-2 Protein, Human (T253M, Q257L, His)

HY-P700618

2 μg;5 μg;10 μg;20 μg;50 μg;100 μg;500 μg;1 mg

33;62;100;160;320;544;1088;1630 USD

SHP-2 Protein, Human (T253M, Q257L, His)

proteins

E. coli

2 μg;5 μg;10 μg;20 μg;50 μg;100 μg;500 μg;1 mg

33;62;100;160;320;544;1088;1630 USD

The SHP-2 protein is a key player downstream of the receptor and cytoplasmic protein tyrosine kinases, facilitating signal transduction from the cell surface to the nucleus. It actively regulates the MAPK pathway and dephosphorylates key substrates, including GAB1, ARHGAP35, EGFR, ROCK2 ("Tyr-722"), and CDC73. SHP-2 Protein, Human (T253M, Q257L, His) is the recombinant human-derived SHP-2 protein, expressed by E. coli , with N-6*His labeled tag and T253M, Q257L, , , mutation. The total length of SHP-2 Protein, Human (T253M, Q257L, His) is 592 a.a., with molecular weight of 70-75 kDa.

Human

SHP-2 protein functions downstream of various receptor and cytoplasmic protein tyrosine kinases, participating in signal transduction from the cell surface to the nucleus. It positively regulates the MAPK signal transduction pathway and plays a crucial role in dephosphorylating key substrates, including GAB1, ARHGAP35, EGFR, ROCK2 (at 'Tyr-722'), and CDC73. Additionally, SHP-2 dephosphorylates SOX9 on tyrosine residues, leading to the inactivation of SOX9 and the promotion of ossification. Furthermore, it targets tyrosine-phosphorylated NEDD9/CAS-L for dephosphorylation, highlighting its diverse roles in modulating cellular signaling cascades.

protein tyrosine phosphatase, non-receptor type 11; Noonan syndrome 1 , NS1; tyrosine-protein phosphatase non-receptor type 11; BPTP3; PTP2C; SH PTP2; SHP 2; SHP2; PTP-2C; protein tyrosine phosphatase-2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; CFC; NS1; PTP-1D; SH-PTP2; SH-PTP3; MGC14433;

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 40 mM Tris, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 6% Trehalose, pH 8.0 or PBS, 6% Trehalose, pH 7.4 or PBS, pH 8.0, 8% trehalose.

Room temperature in continental US; may vary elsewhere.