protein

Angiopoietin-1 Protein, Human (HEK293, Fc)

HY-P70061

2 μg;10 μg;50 μg;100 μg;500 μg

35;95;260;450;1350 USD

Angiopoietin-1 Protein, Human (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg

35;95;260;450;1350 USD

Angiopoietin-1 Protein, Human (HEK 293, Fc) is a secreted protein located on the outside of cell membranes and is an agonistic ligand of receptor tyrosine kinase that is mainly expressed by vascular endothelial cells and hematopoietic cells. Angiopoietin-1 Protein, Human (HEK 293, Fc) is a potent inducer of sprouting angiogenesis, proming for research of colorectal cancer liver metastases (CRCLMs). Angiopoietin-1 Protein, Human (HEK 293, Fc) induces vascular remodeling through highly organized angiogenesis and tightening of endothelial cell (EC) junctions. Angiopoietin-1 Protein, Human (HEK 293, Fc) regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and maintenance of vascular quiescence. Angiopoietin-1 Protein, Human (HEK 293, Fc) is a recombinant protein with a Fc label that consisting of 498 amino acids and is expressed in HEK293 cells [1] [2] [3] [4] [5] [6] [7] .

Human

Angiopoietin-1 Protein, Human (HEK 293, Fc) is a secreted protein ligand for ‘tunica interna endothelial cell kinase’, Tek (Tie2), which is primarily expressed in growing vascular ECs and a subset of hematopoietic cells [1] . Angiopoietin-1 Protein, Human (HEK 293, Fc) induces distinct angiogenesis through both vascular Tie2 and integrin signaling and nonvascular integrin signaling. Angiopoietin-1 Protein is a potential growth factor for therapeutic angiogenesis and vascular stabilization [1] . Angiopoietin-1 Protein, Human (HEK 293, Fc) contains a carboxyl-terminal fibrinogen-like domain that binds to the Tie2 receptor, a central coiled-coil domain that enables oligomerization of these fibrinogen-like domains and a short amino-terminal domain that superclusters the oligomers into variably sizedmultimers [2] . Angiopoietin-1 Protein, Human (HEK 293, Fc) (0.5-10 nM) induces the formation of capillary sprouts in a dose-dependent manner that is completely inhibited by soluble Tie2 receptor extracellular domains in human umbilical vein endothelial cells [4] . Both the human and mouse Angiopoietin-1 cDNA clones reveals open reading frames encoding 498 amino acids and sharing 97.6% identity [5] . Angiopoietin-1 Protein, Human (HEK 293, Fc) promotes TKI-resistance via activation of JAK/STAT5 pathway in chronic myeloid leukemia [7] .

rHuAngiopoietin-1/ANG1, Fc; AGP1; AGPT; Ang1; ANG-1; angiopoietin 1; Angiopoietin-1; ANGPT1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween80 or PBS, pH 7.4, 8% trehalose or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.