protein

BACE1 Protein, Human (HEK293, N-His)

HY-P700606

5 μg;10 μg;50 μg;100 μg

35;55;130;210 USD

BACE1 Protein, Human (HEK293, N-His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;55;130;210 USD

BACE1 protein is crucial in proteolytic processing of amyloid precursor protein (APP), initiating cleavage at the N-terminus of the A-beta peptide sequence. This process results in the extracellular release of beta-cleaved soluble APP and a cell-associated C-terminal fragment. BACE1's cleavage activity extends to CHL1, demonstrating its versatility in substrate processing. BACE1 Protein, Human (HEK293, N-His) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with N-6*His labeled tag.

Human

The BACE1 protein plays a pivotal role in the proteolytic processing of the amyloid precursor protein (APP). It initiates cleavage at the N-terminus of the A-beta peptide sequence, specifically between residues 671 and 672 of APP, resulting in the production and subsequent extracellular release of beta-cleaved soluble APP. Simultaneously, BACE1 generates a corresponding cell-associated C-terminal fragment, subsequently released by gamma-secretase. In addition to its primary target, BACE1 also exhibits cleavage activity on CHL1, as observed through its similarity in cleaving this substrate.

Beta-secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.