protein

CXADR Protein, Mouse (HEK293, Fc)

HY-P70052

10 μg;50 μg;100 μg;500 μg;1 mg

85;240;400;1140;1700 USD

CXADR Protein, Mouse (HEK293, Fc)

proteins

HEK293

10 μg;50 μg;100 μg;500 μg;1 mg

85;240;400;1140;1700 USD

CXADR protein is a key component of the epithelial apical junction complex, which maintains the integrity of tight junctions and enables leukocyte migration through adhesive interactions with JAML. This interaction activates γ-δ T cells and promotes tissue repair through cell signaling involving PI3 kinase and MAP kinase. CXADR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CXADR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CXADR Protein, Mouse (HEK293, Fc) is 218 a.a., with molecular weight of 50-70 kDa.

Mouse

As a vital component of the epithelial apical junction complex, CXADR serves a dual role in maintaining tight junction integrity as a homophilic cell adhesion molecule and facilitating the transepithelial migration of leukocytes through adhesive interactions with Junctional Adhesion Molecule-Like (JAML), a transmembrane protein on the plasma membrane of leukocytes. This interaction between CXADR and JAML is pivotal for the activation of gamma-delta T-cells, a specialized T-cell subpopulation residing in epithelial tissues, contributing to tissue homeostasis and repair. Upon binding to CXADR, JAML initiates downstream cell signaling in gamma-delta T-cells through pathways involving PI3-kinase and MAP kinases, resulting in T-cell proliferation and the production of cytokines and growth factors. This, in turn, stimulates the repair of epithelial tissues. CXADR may exist as a monomer or form homodimers, and it interacts with various proteins, including LNX, MAGI1, DLG4, PRKCABP, TJP1, CTNNB1, and MPDZ, with the latter recruiting MPDZ to intercellular contact sites. Additionally, CXADR engages in homodimeric interactions with JAML, contributing to its multifaceted cellular functions.

rMuCoxsackievirus and adenovirus receptor homolog/CXADR, Fc; Coxsackievirus and adenovirus receptor homolog; CAR; Cxadr; CVB3 BP

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Or lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.