protein

TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His)

HY-P700470

20 μg;50 μg

290;550 USD

TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg

290;550 USD

TMEFF2/Tomoregulin-2 protein serves as a potential survival factor for hippocampal and midbrain neurons, supporting neuronal cell viability.In addition, its shed form may upregulate cancer cell proliferation by promoting ERK1/2 phosphorylation.TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) is the recombinant human-derived TMEFF2/Tomoregulin-2 protein, expressed by HEK293 , with C-10*His labeled tag.

Human

TMEFF2/Tomoregulin-2 Protein emerges as a potential survival factor for hippocampal and mesencephalic neurons, indicating its role in supporting the viability of neural cells. In addition to its neuroprotective function, the shedded form of TMEFF2/Tomoregulin-2 is implicated in up-regulating cancer cell proliferation, potentially by facilitating ERK1/2 phosphorylation. This dual role suggests a complex involvement in both neuronal survival and cancer cell proliferation, highlighting the versatility of TMEFF2 in diverse cellular contexts. Further exploration of the mechanisms underlying TMEFF2's impact on neuronal and cancer cell functions could provide valuable insights into its specific roles and potential therapeutic implications in neural and cancer biology.

TMEFF2; transmembrane protein with EGF like and two follistatin like domains 2; TR; HPP1; TPEF; TR-2; TENB2; CT120.2; tomoregulin-2; cancer/testis antigen family 120, member 2; hyperplastic polyposis protein 1; transmembrane protein TENB2; transmembrane protein with EGF-like and two follistatin-like domains

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0

Room temperature in continental US; may vary elsewhere.