protein

Endothelin-1/EDN1 Protein, Human (GST)

HY-P700460

20 μg;50 μg

150;330 USD

Endothelin-1/EDN1 Protein, Human (GST)

proteins

E. coli

20 μg;50 μg

150;330 USD

Endothelin-1/EDN1, an endothelium-derived vasoconstrictor peptide, acts as a likely ligand for G-protein coupled receptors EDNRA and EDNRB. Its binding initiates a signaling cascade in glomerular mesangial cells involving PTK2B, BCAR1, BCAR3, and GTPases RAP1 and RHOA. Furthermore, Endothelin-1/EDN1 shows binding affinity for the DEAR/FBXW7-AS1 receptor, underscoring its involvement in diverse cellular signaling and vascular regulation. Endothelin-1/EDN1 Protein, Human (GST) is the recombinant human-derived Endothelin-1/EDN1 protein, expressed by E. coli , with N-GST labeled tag. The total length of Endothelin-1/EDN1 Protein, Human (GST) is 21 a.a., with molecular weight of 29.5 kDa.

Human

Endothelin-1/EDN1, a vasoconstrictor peptide derived from the endothelium, serves as a probable ligand for G-protein coupled receptors EDNRA and EDNRB. Upon binding, it activates a signaling cascade involving PTK2B, BCAR1, BCAR3, and GTPases RAP1 and RHOA in glomerular mesangial cells. Additionally, Endothelin-1/EDN1 exhibits binding affinity for the DEAR/FBXW7-AS1 receptor, contributing to its diverse roles in cellular signaling and vascular regulation.

Preproendothelin-1 ; PPET1

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.