protein

Cyclin-H/CCNH Protein, Human (His)

HY-P70041

10 μg;50 μg

190;530 USD

Cyclin-H/CCNH Protein, Human (His)

proteins

E. coli

10 μg;50 μg

190;530 USD

Cyclin-H/CCNH plays a key role as a modulator of CDK7, the catalytic subunit of the CDK-activated kinase (CAK) complex. This enzyme complex activates cyclin-related kinases such as CDK1, CDK2, CDK4, and CDK6 through threonine phosphorylation. Cyclin-H/CCNH Protein, Human (His) is the recombinant human-derived Cyclin-H/CCNH protein, expressed by E. coli , with N-6*His labeled tag. The total length of Cyclin-H/CCNH Protein, Human (His) is 323 a.a., with molecular weight of 34-39 kDa.

Human

The Cyclin-H/CCNH protein functions as a pivotal regulator of CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK, in turn, plays a crucial role in activating cyclin-associated kinases such as CDK1, CDK2, CDK4, and CDK6 through threonine phosphorylation. In association with the core-TFIIH basal transcription factor, CAK facilitates RNA polymerase II activation by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing the polymerase to escape from the promoter and initiate transcript elongation. Cyclin-H/CCNH is actively involved in cell cycle control and RNA transcription by RNA polymerase II, with its expression and activity remaining constant throughout the cell cycle. It primarily associates with CDK7 and MAT1 to form the CAK complex, which, in turn, can further associate with the core-TFIIH to constitute the TFIIH basal transcription factor. These regulatory interactions highlight Cyclin-H/CCNH's central role in coordinating key cellular processes essential for proper cell cycle progression and transcriptional control.

rHuCyclin-H/CCNH, His; Cyclin-H; CCNH; MO15-associated protein; p34; p37

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 2 mM EDTA, 2 mM DTT, 30% Glycerol, pH 8.5.

Shipping with dry ice.