protein

ANGPT2/Angiopoietin-2, Dog (HEK293, His)

HY-P700396

20 μg;50 μg

260;520 USD

ANGPT2/Angiopoietin-2, Dog (HEK293, His)

proteins

HEK293

20 μg;50 μg

260;520 USD

ANGPT2/Angiopoietin-2 (dog) complexly regulates angiogenesis by binding to TEK/TIE2, competitively affecting ANGPT1 signaling. It independently induces TEK/TIE2 phosphorylation and, in the absence of VEGF, may cause endothelial cell apoptosis, thereby promoting vascular regression. ANGPT2/Angiopoietin-2, Dog (HEK293, His) is the recombinant dog-derived ANGPT2/Angiopoietin-2, Dog, expressed by HEK293 , with C-6*His labeled tag. The total length of ANGPT2/Angiopoietin-2, Dog (HEK293, His) is 477 a.a.

Dog

The Dog Angiopoietin-2 protein (ANGPT2) engages in a multifaceted role as it binds to TEK/TIE2, competing for the ANGPT1 binding site and effectively modulating ANGPT1 signaling. Notably, ANGPT2 has the capacity to induce tyrosine phosphorylation of TEK/TIE2 even in the absence of ANGPT1. Its function extends to angiogenesis regulation, where in the absence of angiogenic inducers like VEGF, ANGPT2-mediated loosening of cell-matrix contacts may lead to endothelial cell apoptosis, contributing to vascular regression. Conversely, in collaboration with VEGF, ANGPT2 can facilitate endothelial cell migration and proliferation, acting as a permissive angiogenic signal. Furthermore, ANGPT2 is implicated in the regulation of lymphangiogenesis. The protein's interactions with TEK/TIE2, competing for the same binding site as ANGPT1, and with ITGA5 underscore its comprehensive role in angiogenesis and vascular regulation within the context of dog biology.

angiopoietin 2; angiopoietin-2; Ang2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; ANG2; AGPT2;

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM MOPS, 150 mM NaCl, pH 7.4-7.5, 8% trehalose.

Room temperature in continental US; may vary elsewhere.