protein

Deoxyhypusine synthase/DHS Protein, Human (His)

HY-P70038

10 μg;50 μg

107;300 USD

Deoxyhypusine synthase/DHS Protein, Human (His)

proteins

E. coli

10 μg;50 μg

107;300 USD

The deoxyhorseuridine synthase (DHS) protein plays a crucial role in the NAD-dependent oxidative cleavage of spermidine, followed by the transfer of the butylamine moiety of spermidine to the ε-amino group of the eIF-5A precursor protein. On the key lysine. Deoxyhypusine synthase/DHS Protein, Human (His) is the recombinant human-derived Deoxyhypusine synthase/DHS protein, expressed by E. coli , with C-6*His labeled tag. The total length of Deoxyhypusine synthase/DHS Protein, Human (His) is 369 a.a., with molecular weight of ~44.52 kDa.

Human

Deoxyhypusine synthase (DHS) plays a crucial role in the post-translational modification of the eIF-5A precursor protein. Catalyzing the NAD-dependent oxidative cleavage of spermidine, DHS subsequently transfers the butylamine moiety of spermidine to the epsilon-amino group of a lysine residue on the eIF-5A precursor. This process leads to the formation of the intermediate deoxyhypusine residue, representing the initial step in the conversion of the lysine into an atypical amino acid called hypusine. Hypusination is a unique modification specific to mature eIF-5A and is essential for its proper functioning.

rHuDeoxyhypusine synthase/DHS, His; Deoxyhypusine Synthase; DHS; DHPS; DS

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 20% Glycerol, pH 8.0.

Shipping with dry ice.