protein

CHI3L1 Protein, Human (HEK293, His)

HY-P70030

2 μg;10 μg;50 μg

35;90;270 USD

CHI3L1 Protein, Human (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg

35;90;270 USD

The CHI3L1 protein is a binding lectin that lacks chitinase activity. CHI3L1 contributes to tissue remodeling, cellular adaptation to environmental changes, and T helper type 2 inflammatory responses. CHI3L1 also controls hyperoxia-induced injury, inflammation, and epithelial cell apoptosis. CHI3L1 Protein, Human (HEK293, His) is the recombinant human-derived CHI3L1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CHI3L1 Protein, Human (HEK293, His) is 362 a.a., with molecular weight of 41-48 kDa.

Human

Chitinase-3-like protein 1 (CHI3L1) is a carbohydrate-binding lectin with a specific affinity for chitin, although it lacks chitinase activity. Its main role extends beyond chitin degradation, as it is implicated in tissue remodeling and cellular responses to environmental changes. CHI3L1 plays a crucial role in T-helper cell type 2 (Th2) inflammatory responses and IL-13-induced inflammation, influencing allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation, and the differentiation of M2 macrophages. Additionally, it facilitates the invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. CHI3L1 is involved in the activation of the AKT1 signaling pathway, leading to IL8 production in colonic epithelial cells. Furthermore, it regulates antibacterial responses in the lungs, contributing to macrophage bacterial killing, controlling bacterial dissemination, and enhancing host tolerance. In lung tissues, CHI3L1 also plays a role in regulating hyperoxia-induced injury, inflammation, and epithelial apoptosis. Structurally, CHI3L1 functions as a monomer.

rHuChitinase-3-like protein 1/CHI3L1, His; Chitinase-3-Like protein 1; 39 kDa Synovial Protein; Cartilage Glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40; CHI3L1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 2 mM EDTA, pH 7.4 or 20 mM Tris-HCl, 300 mM NaCl, 2 mM EDTA, pH8.5.

Room temperature in continental US; may vary elsewhere.