protein

BCAS2 Protein, Human (N-GST)

HY-P700271

20 μg;50 μg

165;360 USD

BCAS2 Protein, Human (N-GST)

proteins

E. coli

20 μg;50 μg

165;360 USD

BCAS2 is essential for pre-mRNA splicing and is critical for spliceosome activation as a key component of the activated spliceosome and the PRP19-CDC5L complex. It may act as a scaffold in spliceosome assembly, forming contacts with core components. BCAS2 Protein, Human (N-GST) is the recombinant human-derived BCAS2 protein, expressed by E. coli , with N-GST labeled tag. The total length of BCAS2 Protein, Human (N-GST) is 224 a.a., with molecular weight of ~53 kDa.

Human

BCAS2 is essential for pre-mRNA splicing, functioning as a crucial component of the activated spliceosome and the PRP19-CDC5L complex, which is integral to spliceosome activation. It plays a potential scaffolding role in spliceosome assembly by establishing contacts with all other core complex components. The PRP19-CDC5L complex, of which BCAS2 is a part, may also be implicated in the DNA damage response (DDR). BCAS2 is found in both pre-catalytic and catalytic spliceosome complexes, as well as the postcatalytic spliceosome P complex. The PRP19-CDC5L splicing complex, featuring a homotetramer of PRPF19, CDC5L, PLRG1, and BCAS2 as its core, also includes less stably associated proteins like CTNNBL1, CWC15, and HSPA8. BCAS2 directly interacts with PRPF19, CDC5L, and PLRG1 within this complex.

rHuBCAS2, His, N-T7; Pre-mRNA-Splicing Factor SPF27; Breast Carcinoma-Amplified Sequence 2; Spliceosome-Associated Protein SPF 27; BCAS2

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of Tris-based buffer, 50% glycerol

Room temperature in continental US; may vary elsewhere.