protein

TNFR-1/CD120a Protein, Human (HEK293, His)

HY-P700263

5 μg;10 μg;50 μg;100 μg

42;71;200;350 USD

TNFR-1/CD120a Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

42;71;200;350 USD

The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, His) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-8*His labeled tag. The total length of TNFR-1/CD120a Protein, Human (HEK293, His) is 182 a.a., with molecular weight of 28-38 kDa.

Human

The TNFR-1/CD120a protein acts as a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. Upon TNF binding, the adapter molecule FADD recruits caspase-8 to the activated receptor, initiating the formation of the death-inducing signaling complex (DISC). This complex leads to caspase-8 proteolytic activation, triggering subsequent caspase-mediated apoptosis. TNFR-1/CD120a is involved in the induction of non-cytocidal TNF effects, including the establishment of an anti-viral state and activation of acid sphingomyelinase. Homotrimerization of TNFR-1/CD120a upon TNF binding provides a molecular interface for specific interactions with the death domain of TRADD, recruiting various TRADD-interacting proteins such as TRAFS, RIPK1, and possibly FADD. This complex activates distinct signaling cascades, including apoptosis and NF-kappa-B signaling. Additionally, TNFR-1/CD120a interacts with a variety of proteins, including BAG4, BABAM2, FEM1B, GRB2, SQSTM1, TRPC4AP, NOL3, SH3RF2, PGLYRP1, and MADD, playing a role in modulating the TNF-signaling pathway and apoptosis induction.

Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.