protein

Animal-Free IL-1 beta Protein, Pig (His)

HY-P700243AF

10 μg;50 μg

230;650 USD

Animal-Free IL-1 beta Protein, Pig (His)

proteins

E. coli

10 μg;50 μg

230;650 USD

IL-1 beta protein is a potent proinflammatory cytokine that initiates various immune responses, including prostaglandin synthesis, neutrophil recruitment, T cell cytokine production, B cell activation, fibroblast proliferation, and collagen produce. It promotes Th17 differentiation, synergizes with IL12 to promote IFNG synthesis by Th1 cells, and induces angiogenesis together with TNF and IL6. Animal-Free IL-1 beta Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-1 beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-1 beta Protein, Pig (His) is 153 a.a., with molecular weight of ~18.51 kDa.This product is for cell culture use only.

Pig

IL-1 beta Protein is a potent pro-inflammatory cytokine that was initially discovered as a major endogenous pyrogen. It triggers various immune responses, including the synthesis of prostaglandins, recruitment and activation of neutrophils, activation and production of cytokines by T-cells, activation of B-cells leading to antibody production, and stimulation of fibroblast proliferation and collagen production. Additionally, it plays a role in promoting Th17 differentiation of T-cells and synergizes with IL12 to induce IFNG synthesis by Th1 cells. IL-1 beta Protein also contributes to angiogenesis by synergistically inducing VEGF production along with TNF and IL6. Moreover, it is involved in the transduction of inflammation downstream of pyroptosis, where its mature form is specifically released into the extracellular space through the gasdermin-D (GSDMD) pore. IL-1 beta Protein also interacts with African swine fever virus (ASFV) protein L83L during microbial infections.

Interleukin-1 beta; IL-1β; IL1F2; IL-1 beta; IL1B

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

Room temperature in continental US; may vary elsewhere.