protein

Animal-Free MCP-1/CCL2 Protein, Pig (His)

HY-P700231AF

2 μg;10 μg;50 μg

82;230;650 USD

Animal-Free MCP-1/CCL2 Protein, Pig (His)

proteins

E. coli

2 μg;10 μg;50 μg

82;230;650 USD

MCP-1/CCL2 protein acts as a ligand for CCR2, inducing chemotactic responses and calcium mobilization. It attracts monocytes and basophils but not neutrophils or eosinophils. Animal-Free MCP-1/CCL2 Protein, Pig (His) is the recombinant pig-derived animal-Free MCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag.This product is for cell culture use only.

Pig

CCL2 protein functions as a ligand for C-C chemokine receptor CCR2, initiating a potent chemotactic response and intracellular calcium mobilization through the binding and activation of CCR2. It exhibits chemotactic activity for monocytes and basophils while remaining inactive towards neutrophils or eosinophils. Playing a crucial role in mediating neuropathic pain induced by peripheral nerve injury, CCL2 also enhances NMDA-mediated synaptic transmission in dopamine D1 and D2 receptor-containing neurons, possibly involving MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Existing as a monomer or homodimer in equilibrium, it is tethered to endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans and interacts with TNFAIP6 through its Link domain.

C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 1X PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.