protein

Animal-Free TNF beta Protein, Mouse (His)

HY-P700228AF

2 μg;10 μg;50 μg

35;125;350 USD

Animal-Free TNF beta Protein, Mouse (His)

proteins

E. coli

2 μg;10 μg;50 μg

35;125;350 USD

The animal-free TNF beta protein acts as a homotrimeric cytokine that binds TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM.Animal-Free TNF beta Protein, Mouse (His) is the recombinant mouse-derived animal-FreeTNF beta protein, expressed by E.coli , with N-His labeled tag.This product is for cell culture use only.

Mouse

The TNF beta Protein, in its homotrimeric form, functions by binding to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM, displaying a high degree of similarity in its interactions. In its heterotrimeric form, formed with LTB, it binds to TNFRSF3/LTBR, revealing its versatility in receptor interactions. Produced by lymphocytes, lymphotoxin, the heterotrimeric form of TNF beta, demonstrates cytotoxicity against a broad spectrum of tumor cells both in vitro and in vivo. It exists as homotrimeric and heterotrimeric complexes, with the latter composed of either two LTB and one LTA subunits or, to a lesser extent, two LTA and one LTB subunits. Notably, TNF beta interacts with TNFRSF14, further contributing to its diverse immunomodulatory functions.

TNFSF1B; Lymphotoxin-alpha (LT-α); LTalpha; Ltx; TNF-be; TNFSF1; Tnf; Tnfb; Tnfsf; Tnfsf1b; Tnlg1e; hlb38; hlb382; lymph

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 8.0, trehalose.

Room temperature in continental US; may vary elsewhere.