protein

Animal-Free TGF beta 1/TGFB1 Protein, Mouse (His)

HY-P700227AF

10 μg;50 μg

300;830 USD

Animal-Free TGF beta 1/TGFB1 Protein, Mouse (His)

proteins

E. coli

10 μg;50 μg

300;830 USD

In its proprotein form, the TGF beta-1/TGFB1 protein serves as a precursor to latency-associated peptide (LAP) and active transforming growth factor beta-1 (TGF-beta-1) chains.Critical to maintaining the latent state of TGF-β-1 within the extracellular matrix, preprotein interacts with “environmental molecules” such as LTBP1, LRRC32/GARP, and LRRC33/NRROS to regulate TGF-β-1 activation.Animal-Free TGF beta 1/TGFB1 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeTGF beta 1/TGFB1 protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

Mouse

The TGF beta-1 (TGFB1) protein, in its proprotein form, serves as a precursor for both the Latency-associated peptide (LAP) and the active Transforming growth factor beta-1 (TGF-beta-1) chains. This proprotein is crucial for maintaining the TGF-beta-1 chain in a latent state during storage within the extracellular matrix. The interaction with various 'milieu molecules,' including LTBP1, LRRC32/GARP, and LRRC33/NRROS, plays a pivotal role in regulating the activation of TGF-beta-1. Specifically, LRRC33/NRROS is involved in the activation of TGF-beta-1 in macrophages and microglia, while LRRC32/GARP controls its activation on the surface of activated regulatory T-cells (Tregs). Additionally, the proprotein interacts with integrins (ITGAV:ITGB6 or ITGAV:ITGB8), leading to the distortion of the Latency-associated peptide chain and subsequent release of active TGF-beta-1.

rMuTGF-beta 1/TGFB1; Transforming growth factor beta-1; TGF-β1; LAP

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5, trehalose.

Room temperature in continental US; may vary elsewhere.