protein

Animal-Free IL-36 gamma/IL-1F9 Protein, Mouse (His)

HY-P700211AF

2 μg;10 μg;50 μg

108;325;980 USD

Animal-Free IL-36 gamma/IL-1F9 Protein, Mouse (His)

proteins

E. coli

2 μg;10 μg;50 μg

108;325;980 USD

IL-36 gamma/IL-1F9 protein activates NF-κB through IL1RL2 and promotes local inflammatory responses in the epithelial barrier. It affects keratinocytes, dendritic cells and T cells, promoting tissue infiltration, cell maturation and proliferation. Animal-Free IL-36 gamma/IL-1F9 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-36 gamma/IL-1F9 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-36 gamma/IL-1F9 Protein, Mouse (His) is 152 a.a., with molecular weight of ~18.27 kDa.This product is for cell culture use only.

Mouse

IL-36 gamma/IL-1F9 Protein acts as an agonist, activating NF-kappa B through the orphan IL-1-receptor-related protein 2/IL1RL2. As part of the IL-36 signaling system, it is believed to be present in epithelial barriers, contributing to local inflammatory responses, akin to the IL-1 system, sharing the coreceptor IL1RAP. This protein is implicated in skin inflammatory responses, influencing keratinocytes, dendritic cells, and, indirectly, T-cells to drive tissue infiltration, cell maturation, and proliferation. Additionally, it may play a role in pro-inflammatory responses during specific neutrophilic airway inflammations and contribute to the innate immune response against fungal pathogens. IL-36 gamma induces the production of various pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs) and enhances dendritic cell maturation by stimulating the surface expression of CD80, CD86, and MHC class II. Furthermore, it induces the production of IFN-gamma, IL-4, and IL-17 in cultured CD4(+) T-cells and splenocytes. The protein interacts with the cargo receptor TMED10, mediating translocation from the cytoplasm into the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) and subsequent secretion.

Interleukin-36 gamma; IL-36γ; IL36G; IL-1F9; IL-1H1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

Room temperature in continental US; may vary elsewhere.