protein

Animal-Free IL-36 alpha/IL-1F6 Protein, Mouse (His)

HY-P700210AF

2 μg;10 μg;50 μg

65;180;540 USD

Animal-Free IL-36 alpha/IL-1F6 Protein, Mouse (His)

proteins

E. coli

2 μg;10 μg;50 μg

65;180;540 USD

IL-36 alpha protein binds to the IL1RL2/IL-36R receptor and activates the NF-kappa-B and MAPK signaling pathways. Animal-Free IL-36 alpha/IL-1F6 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-36 alpha/IL-1F6 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

Mouse

IL-36 alpha protein, a cytokine, binds to and signals through the IL1RL2/IL-36R receptor, activating NF-kappa-B and MAPK signaling pathways in target cells, thereby contributing to a pro-inflammatory response. As part of the IL-36 signaling system present in epithelial barriers and sharing similarities with the IL-1 system, IL-36 alpha seems integral to local inflammatory responses. It plays a crucial role in the skin inflammatory response by influencing keratinocytes, dendritic cells, and indirectly impacting T-cells, driving tissue infiltration, cell maturation, and proliferation. IL-36 alpha induces the production of various pro-inflammatory cytokines, including IL-12, IL-1 beta, IL-6, TNF-alpha, and IL-23 in bone marrow-derived dendritic cells (BMDCs), contributing to dendritic cell maturation by stimulating the surface expression of CD80, CD86, and MHC class II. Additionally, IL-36 alpha induces the production of IFN-gamma, IL-4, and IL-17 in cultured CD4(+) T-cells and splenocytes, possibly playing a role in T-cell maturation and proliferation. Its involvement in pro-inflammatory effects extends to the lung, where it induces the expression of CXCL1 and CXCL2 and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1, and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. IL-36 alpha may also be involved in T-cell maturation by stimulating the surface expression of CD40, CD80, and CD86 in splenic CD11c(+) cells. Furthermore, IL-36 alpha induces NF-kappa B activation in macrophages, and its interaction with TMED10 mediates translocation from the cytoplasm into the endoplasmic reticulum-Golgi intermediate compartment (ERGIC), facilitating secretion.

Il36a; Fil1e; Il1e; Il1f6; Il1h1Interleukin-36 alpha; FIL1 epsilon; Interleukin-1 epsilon; IL-1 epsilon; Interleukin-1 family member 6; IL-1F6; Interleukin-1 homolog 1; IL-1H1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

Room temperature in continental US; may vary elsewhere.