protein

Animal-Free IL-12 beta Protein, Mouse (His)

HY-P700191AF

2 μg;10 μg;50 μg

50;135;380 USD

Animal-Free IL-12 beta Protein, Mouse (His)

proteins

E. coli

2 μg;10 μg;50 μg

50;135;380 USD

IL-12 beta protein is a cytokine that acts as a growth factor for activated T cells and NK cells, enhances lytic activity and stimulates IFN-γ production. It combines with IL23A to form IL-23, a cytokine critical in innate and adaptive immunity. Animal-Free IL-12 beta Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-12 beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-12 beta Protein, Mouse (His) is 313 a.a., with molecular weight of ~36.60 kDa.This product is for cell culture use only.

Mouse

The IL-12 beta Protein, a cytokine, functions as a growth factor for activated T and NK cells, enhancing the lytic activity of NK/lymphokine-activated killer cells and stimulating the production of IFN-gamma by resting PBMC. Furthermore, it associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine that plays a crucial role in both innate and adaptive immunity. IL-23, when bound to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, preferentially stimulating memory T-cells over naive T-cells and promoting the production of pro-inflammatory cytokines. This interleukin may constitute, along with IL-17, an acute response to infection in peripheral tissues. However, IL-23's involvement extends to inducing autoimmune inflammation, potentially contributing to autoimmune inflammatory diseases, and it may play a significant role in tumorigenesis.

Interleukin-12 subunit beta; IL-12 subunit p40; IL-12B; Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40); NK cell Stimulating Factor Chain 2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

Room temperature in continental US; may vary elsewhere.