protein

Animal-Free MCP-1/CCL2 Protein, Mouse (His)

HY-P700164AF

2 μg;10 μg;50 μg

55;160;450 USD

Animal-Free MCP-1/CCL2 Protein, Mouse (His)

proteins

E. coli

2 μg;10 μg;50 μg

55;160;450 USD

The MCP-1/CCL2 protein, as a CCR2 ligand, induces potent chemotactic responses and intracellular calcium mobilization in monocytes and basophils, without affecting neutrophils or eosinophils.It is critical for neuropathic pain and enhances NMDA-mediated synaptic transmission in neurons containing dopamine D1 and D2 receptors, possibly involving MAPK/ERK-dependent GRIN2B/NMDAR2B phosphorylation.Animal-Free MCP-1/CCL2 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMCP-1/CCL2 protein, expressed by E.coli , with N-His labeled tag.This product is for cell culture use only.

Mouse

MCP-1/CCL2 protein acts as a ligand for C-C chemokine receptor CCR2, initiating a robust chemotactic response and intracellular calcium mobilization through CCR2 binding and activation. It demonstrates chemotactic activity for monocytes and basophils while not affecting neutrophils or eosinophils. Playing a pivotal role in mediating peripheral nerve injury-induced neuropathic pain, MCP-1/CCL2 also enhances NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, potentially involving MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Existing as a monomer or homodimer in equilibrium, it is tethered to endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans and interacts with TNFAIP6 through its Link domain.

Monocyte Chemotactic Protein-1; MCP-1; JE

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

Room temperature in continental US; may vary elsewhere.