protein

Animal-Free TGF beta 3/TGFB3 Protein, Human (His)

HY-P700152AF

2 μg;10 μg;50 μg

74;219;665 USD

Animal-Free TGF beta 3/TGFB3 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

74;219;665 USD

Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Animal-Free TGF beta 3/TGFB3 Protein, Human (His) is the recombinant human-derived animal-FreeTGF beta 3/TGFB3 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free TGF beta 3/TGFB3 Protein, Human (His) is 112 a.a., with molecular weight of ~13.66 kDa.This product is for cell culture use only.

Human

Latent Transforming growth factor beta-3 (TGF-beta-3) proprotein serves as the precursor for both the Latency-associated peptide (LAP) and the active TGF-beta-3 chains, acting as the regulatory and functional subunits, respectively. It plays a vital role in maintaining the latent state of TGF-beta-3 within the extracellular matrix. Through non-covalent association with TGF-beta-3, Latent TGF-beta-3 actively regulates the activation process by interacting with key 'milieu molecules' such as LTBP1 and LRRC32/GARP. These interactions contribute to the controlled activation of TGF-beta-3, with LTBP1 and LRRC32/GARP acting as crucial components in this regulatory mechanism. Additionally, interaction with integrins induces structural changes in the Latency-associated peptide chain, leading to the subsequent release of active TGF-beta-3. This sophisticated molecular interplay underscores the pivotal role of Latent TGF-beta-3 in orchestrating the regulated activation of TGF-beta-3 in various physiological contexts.

ARVD; ARVD1; LDS5; RNHF; TGFB3; TGF-B3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 0.2 M NaCl, 20 mM sodium citrate, pH 3.5, trehalose or 20 mM sodium citrate and 0.2 M NaCl, pH 4.5.

Room temperature in continental US; may vary elsewhere.