protein

Animal-Free IL-5 Protein, Human (His)

HY-P700131AF

10 μg;50 μg

175;490 USD

Animal-Free IL-5 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

175;490 USD

The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. Animal-Free IL-5 Protein, Human (His) is the recombinant human-derived animal-FreeIL-5 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-5 Protein, Human (His) is 115 a.a., with molecular weight of ~14.09 kDa.This product is for cell culture use only.

Human

IL-5 Protein is a homodimeric cytokine predominantly expressed by T-lymphocytes and NK cells, and it plays a crucial role in the survival, differentiation, and chemotaxis of eosinophils. Additionally, IL-5 Protein acts on both activated and resting B-cells, inducing immunoglobulin production, growth, and differentiation. Its biological effects are mediated through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB, leading to the activation of various kinases such as LYN, SYK, and JAK2. These activated kinases propagate signals through the RAS-MAPK and JAK-STAT5 pathways. IL-5 Protein exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits.

Interleukin-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 8.0, trehalose.

Room temperature in continental US; may vary elsewhere.