protein

Animal-Free IL-36RN Protein, Human (His)

HY-P700127AF

2 μg;10 μg;50 μg

77;215;600 USD

Animal-Free IL-36RN Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

77;215;600 USD

IL-36RN protein tightly regulates immunity by inhibiting the activity of interleukin 36 (IL36A, IL36B, IL36G).It binds to the IL-36 receptor (IL1RL2), preventing binding to IL1RAP and blocking downstream signaling.Animal-Free IL-36RN Protein, Human (His) is the recombinant human-derived animal-FreeIL-36RN protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

Human

IL-36RN protein assumes a critical role in immune regulation by inhibiting the activity of interleukin-36 (IL36A, IL36B, and IL36G). This inhibition is achieved through its binding to the IL-36 receptor (IL1RL2), preventing its association with the coreceptor IL1RAP, thus impeding downstream signaling. As part of the IL-36 signaling system, analogous to the IL-1 system, IL-36RN is believed to function in epithelial barriers, contributing to local inflammatory responses. This protein is implicated in skin inflammation and is proposed to participate in the innate immune response against fungal pathogens, exemplified by its potential role in countering Aspergillus fumigatus. Furthermore, IL-36RN may activate an anti-inflammatory signaling pathway by recruiting SIGIRR. Notably, its interaction with the cargo receptor TMED10 facilitates translocation from the cytoplasm into the ERGIC, enabling secretion and underscoring its multifaceted regulatory functions.

IL-36RA; IL-36Ra; Interleukin-36 Receptor Antagonist Protein; IL-1RP3; Interleukin-1; Interleukin-1 Family Member 5; IL-1F5; Interleukin-1-Like Protein 1; IL-1L1; IL36RN; FIL1D; IL1F5; IL1HY1; IL1RP3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

Room temperature in continental US; may vary elsewhere.