protein

Animal-Free IFN-lambda 2/IL-28A Protein, Human (His)

HY-P700119AF

2 μg;10 μg;50 μg

80;220;590 USD

Animal-Free IFN-lambda 2/IL-28A Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

80;220;590 USD

IFN-lambda 2/IL-28A protein is a multifunctional cytokine with antiviral, antitumor, and immunomodulatory activities. It plays a key role in antiviral host defense, particularly within epithelial tissues. Animal-Free IFN-lambda 2/IL-28A Protein, Human (His) is the recombinant human-derived animal-FreeIFN-lambda 2/IL-28A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-lambda 2/IL-28A Protein, Human (His) is 174 a.a., with molecular weight of ~20.60 kDa.This product is for cell culture use only.

Human

IFN-lambda 2/IL-28A Protein, a versatile cytokine, possesses antiviral, antitumor, and immunomodulatory activities. It assumes a pivotal role in antiviral host defense, particularly within epithelial tissues. Functioning as a ligand for the heterodimeric class II cytokine receptor comprising IL10RB and IFNLR1, its engagement activates the JAK/STAT signaling pathway, leading to the expression of IFN-stimulated genes (ISG) that establish the antiviral state. Notably, its receptor distribution is confined, primarily exerting its effects in epithelial cells due to the cell type-selective expression of the receptor IFNLR1. While not deemed essential for early virus-activated host defense in vaginal infection, it proves vital in Toll-like receptor (TLR)-induced antiviral defense. It plays a significant role in antiviral immune defense within the intestinal epithelium. Furthermore, IFN-lambda 2/IL-28A contributes to immunomodulation by up-regulating MHC class I antigen expression, enhancing its impact on immune responses.

Interferon lambda-2; IFN-lambda-2; IL-28A; IFNL2; IL28A; ZCYTO20

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 8.0, trehalose.

Room temperature in continental US; may vary elsewhere.