protein

Animal-Free IL-27 beta/EBI3 Protein, Human (His)

HY-P700118AF

2 μg;10 μg;50 μg

45;125;350 USD

Animal-Free IL-27 beta/EBI3 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

45;125;350 USD

The IL-27 beta/EBI3 protein binds to IL27 to form IL-27 interleukin, which is critical in innate immunity. IL-27 has both pro- and anti-inflammatory properties, regulating T helper cell development, inhibiting T cell proliferation, stimulating cytotoxic T cell activity, inducing B cell isotype switching, and affecting innate immune cells. Animal-Free IL-27 beta/EBI3 Protein, Human (His) is the recombinant human-derived animal-FreeIL-27 beta/EBI3 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-27 beta/EBI3 Protein, Human (His) is 209 a.a., with molecular weight of ~24.25 kDa.This product is for cell culture use only.

Human

The IL-27 beta/EBI3 Protein associates with IL27 to constitute the IL-27 interleukin, a heterodimeric cytokine that plays a crucial role in innate immunity. Demonstrating both pro- and anti-inflammatory properties, IL-27 regulates T-helper cell development, inhibits T-cell proliferation, stimulates cytotoxic T-cell activity, induces isotype switching in B-cells, and exerts diverse effects on innate immune cells. CD4 T-helper cells, under IL-27 influence, can differentiate into type 1 effector cells (TH1), type 2 effector cells (TH2), and IL-17-producing helper T-cells (TH17). IL-27 facilitates the rapid clonal expansion of naive CD4 T-cells, but not memory CD4 T-cells, and synergizes strongly with IL-12 to induce interferon-gamma/IFN-gamma production by naive CD4 T-cells. Binding to the cytokine receptor WSX-1/TCCR, IL-27 contributes to the antitumor and antiangiogenic activities, leading to the activation of production of antiangiogenic chemokines. It forms heterodimers with IL27/IL27A, recognized as interleukin IL-27, and with IL12A, forming interleukin IL-35, both not disulfide-linked. Additionally, IL-27 interacts with SQSTM1.

Interleukin-27 subunit alpha; IL-27-A; Interleukin-27 subunit beta; IL-27B; Epstein-Barr virus-in_x0002_duced gene 3 protein; EBV-induced gene 3 protein; EBI3; p28; Interleukin-30; IL-30

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 8.0, trehalose.

Room temperature in continental US;may vary elsewhere.