protein

Animal-Free IL-26/AK155 Protein, Human (His)

HY-P700117AF

10 μg;50 μg

213;596 USD

Animal-Free IL-26/AK155 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

213;596 USD

The IL-26/AK155 monomeric protein may play a crucial role in mucosal immunity, and its proinflammatory functions are associated with inflammatory bowel disease. Functionally, it activates various signaling pathways, induces the expression of immune mediators, and reduces intestinal epithelial cell proliferation. Animal-Free IL-26/AK155 Protein, Human (His) is the recombinant human-derived animal-FreeIL-26/AK155 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-26/AK155 Protein, Human (His) is 150 a.a., with molecular weight of ~18.53 kDa.This product is for cell culture use only.

Human

The IL-26/AK155 Monomer protein is implicated in potentially playing a crucial role in local mechanisms of mucosal immunity, suggesting its involvement in the intricate processes of immune regulation within mucosal tissues. It appears to have a pro-inflammatory function and may be associated with inflammatory bowel disease, underscoring its significance in inflammatory processes in the gastrointestinal tract. Functionally, IL-26/AK155 Monomer activates various signaling pathways, including STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN, and AKT, suggesting a broad impact on cellular responses. It induces the expression of SOCS3, TNF-alpha, and IL-8, along with the secretion of IL-8 and IL-10, as well as the surface expression of ICAM1, highlighting its involvement in the regulation of immune and inflammatory mediators. Additionally, IL-26/AK155 Monomer demonstrates the ability to decrease the proliferation of intestinal epithelial cells. Notably, its activity is inhibited by heparin, adding a layer of regulatory control. The structural arrangement involves the formation of homodimers, emphasizing the importance of its oligomeric state in mediating cellular responses and signaling cascades within the context of mucosal immunity.

AK155; IL-26; Interleukin-26; Protein AK155; Interleukin 26

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 8.0, trehalose.

Room temperature in continental US;may vary elsewhere.