protein

Animal-Free MCP-1/CCL2 Protein, Human (His)

HY-P700034AF

2 μg;10 μg;50 μg

75;210;590 USD

Animal-Free MCP-1/CCL2 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

75;210;590 USD

MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. Animal-Free MCP-1/CCL2 Protein, Human (His) is the recombinant human-derived animal-FreeMCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free MCP-1/CCL2 Protein, Human (His) is 76 a.a., with molecular weight of ~9.49 kDa.This product is for cell culture use only.

Human

MCP-1/CCL2, Human, serves as a ligand for C-C chemokine receptor CCR2, initiating a robust chemotactic response and intracellular calcium mobilization upon CCR2 binding and activation. This chemokine exhibits chemotactic activity specifically for monocytes and basophils, excluding neutrophils or eosinophils from its influence. Additionally, MCP-1/CCL2 may play a role in recruiting monocytes to the arterial wall during the progression of atherosclerosis. Existing in equilibrium as a monomer or homodimer, it is anchored to endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Furthermore, MCP-1/CCL2 interacts with TNFAIP6 through its Link domain.

C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 1X PBS, pH 7.4, trehalose.

Room temperature in continental US; may vary elsewhere.