protein

Animal-Free BMP-7 Protein, Human (His)

HY-P700030AF

2 μg;10 μg;50 μg

110;310;870 USD

Animal-Free BMP-7 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

110;310;870 USD

BMP-7 protein is an important member of the TGF-β superfamily and is critical in embryogenesis, hematopoiesis, neurogenesis and bone morphogenesis. It activates canonical BMP signaling through ACVR1 and ACVR2A, phosphorylates and activates ACVR1, which in turn phosphorylates SMAD1/5/8 for target gene transcriptional regulation. Animal-Free BMP-7 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-7 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free BMP-7 Protein, Human (His) is 117 a.a., with molecular weight of ~14.00 kDa.This product is for cell culture use only.

Human

BMP-7 Protein, a vital member of the TGF-beta superfamily, plays a crucial role in various biological processes, encompassing embryogenesis, hematopoiesis, neurogenesis, and skeletal morphogenesis. It initiates the canonical BMP signaling cascade by binding to the type I receptor ACVR1 and the type II receptor ACVR2A, leading to the phosphorylation and activation of ACVR1. Subsequently, ACVR1 phosphorylates SMAD1/5/8, which modulate target gene transcription as activators and repressors in the nucleus. In specific functions, such as growth cone collapse in developing spinal neurons and monocyte chemotaxis, BMP-7 utilizes BMPR2 as an additional type II receptor. Beyond canonical pathways, BMP-7 signals through non-canonical routes, such as the P38 MAP kinase signaling cascade, to promote brown adipocyte differentiation by activating target genes, including members of the SOX family of transcription factors. BMP-7 further regulates the expression of HAMP, with this process being restrained by its interaction with ERFE. This homodimeric protein forms disulfide-linked complexes and interacts with various proteins, including SOSTDC1, TWSG1, FBN1, FBN2, ACVR1, ACVR2A, NOG, SCUBE3, and ERFE, each contributing to its diverse functional repertoire.

Osteogenic Protein-1; OP-1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5, trehalose.

Room temperature in continental US; may vary elsewhere.