protein

Animal-Free BMP-6 Protein, Human (His)

HY-P700029AF

2 μg;10 μg;50 μg

106;298;835 USD

Animal-Free BMP-6 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

106;298;835 USD

BMP-6 protein is a member of the TGF-β superfamily and is critical in various developmental processes including skeletal development. It acts as a key regulator of HAMP/hepcidin expression and iron metabolism via hemojuvelin/HJV. Animal-Free BMP-6 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free BMP-6 Protein, Human (His) is 117 a.a., with molecular weight of ~14.07 kDa.This product is for cell culture use only.

Human

BMP-6 Protein, a member of the TGF-beta superfamily, is indispensable in various developmental processes, including cartilage and bone formation. Beyond its roles in skeletal development, BMP-6 serves as a crucial regulator of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Moreover, it can promote HAMP expression, potentially through interaction with its receptor BMPR1A/ALK3. The initiation of the canonical BMP signaling cascade involves BMP-6 associating with the type I receptor ACVR1 and type II receptor ACVR2B, with ACVR1 propagating signals by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Additionally, BMP-6 can engage non-canonical pathways, such as the TAZ-Hippo signaling cascade, influencing VEGF signaling by regulating VEGFR2 expression. It forms interactions with various proteins, including SOSTDC1, Hemojuvelin/HJV, ERFE, and BMPR1A/ALK3, showcasing its versatile regulatory roles in different cellular processes.

Bone morphogenetic protein 6; Bmp6; BMP-6; VG-1-related protein; VGR-1; Vgr1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 3.5 or PBS, pH 8.0.

Room temperature in continental US; may vary elsewhere.