protein

Animal-Free BMP-4 Protein, Human (His)

HY-P700027AF

2 μg;10 μg;50 μg

84;233;650 USD

Animal-Free BMP-4 Protein, Human (His)

proteins

E. coli

2 μg;10 μg;50 μg

84;233;650 USD

Bone morphogenetic protein 4 (BMP-4) is a polymorphic ligand protein belonging to the TGF-β family, which is involved in the circulation of the vascular system and can activate receptors on vascular cells [1] . BMP-4 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) [2] to increase plaque formation and promote oxidative stress, endothelial dysfunction, and osteogenic differentiation through its pro-inflammatory and pro-atherogenic effects [3] . Animal-Free BMP-4 Protein, Human (His) has a total length of 106 amino acids (K303-R408), is expressed in E. coli cells with a C-terminal His-tag.This product is for cell culture use only.

Human

Bone Morphogenetic Protein 4 (BMP-4) is a ligand protein with pleiotropic, belongs to TGFβ family. BMP-4 involves in the vasculature circulation and can activate receptors on vascular cells [1] . BMP-4/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms [4] . BMP-4 is widely found in different animals, while the sequence in human is highly similar to Rat (96.81%), and mouse (97.54%). BMP-4 is expressed by endothelial cells (ECs) in response to hypoxia and promotes vascular SMC proliferation. Therefore it inhibits the proliferation of smooth muscle cells (SMCs) isolated from the proximal pulmonary artery while induces proliferation of SMCs isolated from distal pulmonary arteries [5] . BMP-4 appears to be a marker and driver of vascular calcification, particularly in atherosclerosis [6] . BMP-4 induces angiogenesis, endothelial cells (ECs) proliferation, and migration [7] . BMP-4 is differentially expressed in calcified atherosclerotic plaques [8] , serves as the linkers between atherosclerotic vascular calcification with mechanisms of normal bone formation [9] . BMP-4 increases plaque formation via their pro-inflammatory and pro-atherogenic effects, promoting oxidative stress, endothelial dysfunction and osteogenic differentiation [3] .

BMP-2B; DVR4

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a solution containing 20 mM sodium carbonate,pH 9.0, trehalose.

Room temperature in continental US; may vary elsewhere.