protein

Animal-Free AITRL/TNFSF18 Protein, Human (His)

HY-P700014AF

2 μg;10 μg;50 μg

60;170;480 USD

Animal-Free AITRL/TNFSF18 Protein, Human (His)

Protein

E. coli

2 μg;10 μg;50 μg

60;170;480 USD

AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). Animal-Free AITRL/TNFSF18 Protein, Human (His) is a recombinant human AITRL (Q49-I174) with C-terminal His tag, which is expressed in E.coli.This product is for cell culture use only.