protein

Tenascin/Tnc protein, Mouse (His-Myc, Solution)

HY-P700002A

5 μg;10 μg;50 μg;100 μg

276;470;1220;1950 USD

Tenascin/Tnc protein, Mouse (His-Myc, Solution)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

276;470;1220;1950 USD

Tenascin/Tnc proteins guide neuronal and axonal migration and contribute to development, synaptic plasticity, and neuronal regeneration.Tenascin/Tnc protein, Mouse (His-Myc, Solution) is the recombinant mouse-derived Tenascin/Tnc protein, expressed by HEK293 , with N-10*His, C-Myc labeled tag.

Mouse

The Tenascin/Tnc protein, an extracellular matrix protein, assumes a critical role in guiding migrating neurons and axons during development, as well as contributing to synaptic plasticity and neuronal regeneration. It not only promotes neurite outgrowth in cultured neurons but also may play a role in supporting the growth of epithelial tumors, underscoring its diverse functional implications. Serving as a ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3, and ITGAV:ITGB6, Tenascin/Tnc establishes molecular interactions essential for cellular communication and signaling. In the context of tumors, it stimulates angiogenesis by facilitating the elongation, migration, and sprouting of endothelial cells. Structurally, Tenascin/Tnc exists as a homohexamer with a potential homotrimer formation in the triple coiled-coil region, further stabilized by disulfide rings at both ends. The interaction with CSPG4 suggests its involvement in intricate cellular and molecular processes across diverse biological contexts.

Tenascin; TN; Hexabrachion; Tenascin-C (TN-C)

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4, 20% Glycerol.

Shipping with dry ice