Published Application/Species/Sample/Dilution | Reference |
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- immunocytochemistry knockout validation; mouse; 1:400; loading ...; fig 1c
- western blot knockout validation; mouse; 1:1000; loading ...; fig 1b
- immunoprecipitation; mouse; loading ...; fig 5b
| Takanezawa Y, Nakamura R, Harada R, Sone Y, Uraguchi S, Kiyono M. Sequestosome1/p62 protects mouse embryonic fibroblasts against low-dose methylercury-induced cytotoxicity and is involved in clearance of ubiquitinated proteins. Sci Rep. 2017;7:16735 pubmed publisher
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- western blot; human; loading ...; fig 3d
| Fang S, Sun S, Cai H, Zou X, Wang S, Hao X, et al. IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1 +/- mice display increases atherosclerotic plaque stability. Theranostics. 2021;11:9358-9375 pubmed publisher
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- western blot; mouse; 1:5000; loading ...; fig s1e
- western blot; human; 1:5000; loading ...; fig 6a
| Yamamuro T, Nakamura S, Yamano Y, Endo T, Yanagawa K, Tokumura A, et al. Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function. PLoS Genet. 2021;17:e1009688 pubmed publisher
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- western blot; mouse; 1:500; loading ...
| Jiao L, Eickhoff R, Egners A, Jumpertz S, Roth J, Erdem M, et al. Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer. J Pathol. 2021;255:270-284 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:200; fig 7j
- western blot; human; 1:1000; loading ...; fig 5j
| Chen Y, Jia Y, Mao M, Gu Y, Xu C, Yang J, et al. PLAC8 promotes adriamycin resistance via blocking autophagy in breast cancer. J Cell Mol Med. 2021;25:6948-6962 pubmed publisher
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- immunohistochemistry; mouse; 1:200; loading ...; fig 7j
| Subramanian M, Hyeon S, Das T, Suh Y, Kim Y, Lee J, et al. UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021;12:3291 pubmed publisher
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- western blot; Japanese rice fish; 1:500; loading ...; fig 5a
| Nakanishi E, Uemura N, Akiyama H, Kinoshita M, Masanori S, Taruno Y, et al. Impact of Gba2 on neuronopathic Gaucher's disease and α-synuclein accumulation in medaka (Oryzias latipes). Mol Brain. 2021;14:80 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 3e
| Wang Y, Lee Y, Hsu Y, Chiu I, Huang C, Huang C, et al. The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice. Environ Health Perspect. 2021;129:57003 pubmed publisher
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- immunohistochemistry - paraffin section; human; loading ...; fig 7a
- western blot; human; loading ...; fig 1a
| Feng L, Chen M, Li Y, Li M, Hu S, Zhou B, et al. Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis. Cell Death Dis. 2021;12:405 pubmed publisher
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- immunohistochemistry; mouse; 1:300; loading ...; fig 2b
| Kakehashi A, Chariyakornkul A, Suzuki S, Khuanphram N, Tatsumi K, Yamano S, et al. Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. Cancers (Basel). 2021;13: pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:15,000; loading ...; fig 2e
- western blot; mouse; loading ...; fig 1c
| Iwama H, Mehanna S, Imasaka M, Hashidume S, Nishiura H, Yamamura K, et al. Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis. Sci Rep. 2021;11:6596 pubmed publisher
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- western blot; mouse; loading ...; fig 5c
| Yagisawa Y, Suita K, Ohnuki Y, Ishikawa M, Mototani Y, Ito A, et al. Effects of occlusal disharmony on cardiac fibrosis, myocyte apoptosis and myocyte oxidative DNA damage in mice. PLoS ONE. 2020;15:e0236547 pubmed publisher
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- immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 1c
| Lieberman O, Frier M, McGuirt A, Griffey C, Rafikian E, Yang M, et al. Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy. elife. 2020;9: pubmed publisher
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- western blot; human; loading ...; fig 1a
| Chen Y, Wu J, Liang G, Geng G, Zhao F, Yin P, et al. CHK2-FOXK axis promotes transcriptional control of autophagy programs. Sci Adv. 2020;6:eaax5819 pubmed publisher
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- immunocytochemistry; mouse; loading ...; fig 2f
| Lee Y, Yamada H, Pradipta A, Ma J, Okamoto M, Nagaoka H, et al. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense. Life Sci Alliance. 2020;3: pubmed publisher
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- western blot; human; loading ...; fig 3a
| Chino H, Hatta T, Natsume T, Mizushima N. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Mol Cell. 2019;74:909-921.e6 pubmed publisher
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- western blot; mouse; loading ...; fig s2c
| Ding X, Jiang X, Tian R, Zhao P, Li L, Wang X, et al. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy. 2019;:1-13 pubmed publisher
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- western blot; human; loading ...; fig 5a
| Huang X, Gan G, Wang X, Xu T, Xie W. The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. Autophagy. 2019;15:1258-1279 pubmed publisher
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- western blot; mouse; loading ...; fig 6c
| Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed publisher
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- immunohistochemistry; human; 1:2000; loading ...; fig 3c
| Rivera Reyes A, Ye S, E Marino G, Egolf S, E Ciotti G, Chor S, et al. YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma. Cell Death Dis. 2018;9:1108 pubmed publisher
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- western blot; human; loading ...; fig 2e
| Liu X, Cai S, Zhang C, Liu Z, Luo J, Xing B, et al. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucleic Acids Res. 2018;46:9601-9616 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 1c
| Aoki A, Nakashima A, Kusabiraki T, Ono Y, Yoshino O, Muto M, et al. Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension. Am J Pathol. 2018;188:2474-2486 pubmed publisher
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- immunohistochemistry; domestic rabbit; 1:500; loading ...; fig s1
| Alissafi T, Hatzioannou A, Mintzas K, Barouni R, Banos A, Sormendi S, et al. Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells. J Clin Invest. 2018;128:3840-3852 pubmed publisher
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- immunohistochemistry; human; loading ...; fig 2b
- western blot; human; loading ...; fig 2a
| Zaffagnini G, Savova A, Danieli A, Romanov J, Tremel S, Ebner M, et al. p62 filaments capture and present ubiquitinated cargos for autophagy. EMBO J. 2018;37: pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 4a
| Watanabe S, Komine O, Endo F, Wakasugi K, Yamanaka K. Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice. J Neurochem. 2018;145:80-89 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2a
| Schludi M, Becker L, Garrett L, Gendron T, Zhou Q, Schreiber F, et al. Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta Neuropathol. 2017;134:241-254 pubmed publisher
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- immunocytochemistry; human; 1:500; loading ...; fig 7e
| Menges S, Minakaki G, Schaefer P, Meixner H, Prots I, Schlötzer Schrehardt U, et al. Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Sci Rep. 2017;7:42942 pubmed publisher
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- western blot; rat; loading ...; fig 6a
- western blot; mouse; loading ...; fig 4a
| Zhao H, Li X, Zhao T, Zhang H, Yan M, Dong X, et al. Tangshen formula attenuates diabetic renal injuries by upregulating autophagy via inhibition of PLZF expression. PLoS ONE. 2017;12:e0171475 pubmed publisher
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- western blot; mouse; fig 7d
| Wakatsuki S, Tokunaga S, Shibata M, Araki T. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. J Cell Biol. 2017;216:477-493 pubmed publisher
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- western blot; mouse; 1:1000; loading ...; fig 7d
| Lizardo K, Almonte V, Law C, Aiyyappan J, Cui M, Nagajyothi J. Diet regulates liver autophagy differentially in murine acute Trypanosoma cruzi infection. Parasitol Res. 2017;116:711-723 pubmed publisher
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- immunoprecipitation; mouse; 1:5000; loading ...; fig 4f
- immunohistochemistry; mouse; 1:500; loading ...; fig 4g
- western blot; mouse; 1:5000; loading ...; fig 4f
| Watanabe Y, Honda S, Konishi A, Arakawa S, Murohashi M, Yamaguchi H, et al. Autophagy controls centrosome number by degrading Cep63. Nat Commun. 2016;7:13508 pubmed publisher
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- immunohistochemistry; mouse; fig 2
| Yamanaka T, Tosaki A, Miyazaki H, Kurosawa M, Koike M, Uchiyama Y, et al. Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS. Sci Rep. 2016;6:34575 pubmed publisher
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- western blot; human; loading ...; fig 2a
| Zhang Q, Jin R, Zhang X, Sheng J, Yu F, Tan R, et al. The putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatment. Oncotarget. 2016;7:69688-69702 pubmed publisher
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- immunocytochemistry; mouse; loading ...; fig 4f
| Gao Y, Liu Y, Hong L, Yang Z, Cai X, Chen X, et al. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016;7:e2330 pubmed publisher
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- western blot; human; loading ...; fig 2b
| Cheng M, Liu L, Lao Y, Liao W, Liao M, Luo X, et al. MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis. Oncotarget. 2016;7:42274-42287 pubmed publisher
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- immunohistochemistry - paraffin section; human; fig 7
- western blot; human; fig 5
| Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
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- western blot; mouse; 1:2000; fig 7
| Boada Romero E, Serramito Gómez I, Sacristán M, Boone D, Xavier R, Pimentel Muiños F. The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1. Nat Commun. 2016;7:11821 pubmed publisher
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| Wu L, Sun Y, Ma L, Zhu J, Zhang B, Pan Q, et al. A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. Sci Rep. 2016;6:27332 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:9000; fig 4
| Adams O, Dislich B, Berezowska S, Schläfli A, Seiler C, Kröll D, et al. Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. Oncotarget. 2016;7:39241-39255 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 3g
| Wei Z, Yuan Y, Jaouen F, Ma M, Hao C, Zhang Z, et al. SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation. Autophagy. 2016;12:1168-79 pubmed publisher
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- western blot; mouse; loading ...; fig 2d
| Ding Y, Adachi H, Katsuno M, Sahashi K, Kondo N, Iida M, et al. BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1. Neuroscience. 2016;327:20-31 pubmed publisher
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- immunohistochemistry - frozen section; mouse; fig 4
- western blot; mouse; fig 4
| Li M, Lu G, Hu J, Shen X, Ju J, Gao Y, et al. EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy. Stem Cell Reports. 2016;6:396-410 pubmed publisher
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- western blot; mouse; 1:10,000; fig 4
| Puente C, Hendrickson R, Jiang X. Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy. J Biol Chem. 2016;291:6026-35 pubmed publisher
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- immunocytochemistry; mouse; fig 2
- western blot; mouse; fig 1
| Kaizuka T, Mizushima N. Atg13 Is Essential for Autophagy and Cardiac Development in Mice. Mol Cell Biol. 2016;36:585-95 pubmed publisher
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| Ikari S, Yang Q, Lu S, Liu Y, Hao F, Tong G, et al. Quercetin in Tartary Buckwheat Induces Autophagy against Protein Aggregations. Antioxidants (Basel). 2021;10: pubmed publisher
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| Nazio F, Po A, Abballe L, Ballabio C, Diomedi Camassei F, Bordi M, et al. Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling. Acta Neuropathol. 2021;142:537-564 pubmed publisher
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| Janda E, Martino C, Riillo C, Parafati M, Lascala A, Mollace V, et al. Apigenin and Luteolin Regulate Autophagy by Targeting NRH-Quinone Oxidoreductase 2 in Liver Cells. Antioxidants (Basel). 2021;10: pubmed publisher
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| Farré Alins V, Narros Fernández P, Palomino Antolin A, Decouty Pérez C, López Rodríguez A, Parada E, et al. Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux. Antioxidants (Basel). 2020;9: pubmed publisher
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| Aragonès G, Dasuri K, Olukorede O, Francisco S, Renneburg C, Kumsta C, et al. Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability. Aging Cell. 2020;19:e13257 pubmed publisher
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| Chen Y, Zhang P, Lin X, Zhang H, Miao J, Zhou Y, et al. Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats. Aging (Albany NY). 2020;12:17235-17256 pubmed publisher
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| Omi J, Watanabe Takahashi M, Igai K, Shimizu E, Tseng C, Miyasaka T, et al. The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection. Nat Commun. 2020;11:162 pubmed publisher
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| Sn S, Pandurangi J, Murumalla R, Dj V, Garimella L, Acharya A, et al. Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration. EBioMedicine. 2019;50:260-273 pubmed publisher
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| Wang B, Xiao X, Huang F, Liu R. Syntaxin-17-Dependent Mitochondrial Dynamics is Essential for Protection Against Oxidative-Stress-Induced Apoptosis. Antioxidants (Basel). 2019;8: pubmed publisher
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| Ali R, Alabdullah M, Miligy I, Normatova M, Babaei Jadidi R, Nateri A, et al. ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity. Cells. 2019;8: pubmed publisher
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| Tripathi A, Thangaraj A, Chivero E, Periyasamy P, Callen S, Burkovetskaya M, et al. Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction. Cells. 2019;8: pubmed publisher
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| Morishita H, Zhao Y, Tamura N, Nishimura T, Kanda Y, Sakamaki Y, et al. A critical role of VMP1 in lipoprotein secretion. elife. 2019;8: pubmed publisher
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| Yang Y, Willis T, Button R, Strang C, Fu Y, Wen X, et al. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nat Commun. 2019;10:3759 pubmed publisher
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| Hu Z, Chen B, Zhao Q. Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy. Biol Open. 2019;8: pubmed publisher
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| Thangaraj A, Periyasamy P, Guo M, Chivero E, Callen S, Buch S. Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics. Autophagy. 2019;:1-24 pubmed publisher
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| Turco E, Witt M, Abert C, Bock Bierbaum T, Su M, Trapannone R, et al. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol Cell. 2019;74:330-346.e11 pubmed publisher
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| Li C, Huang L, Sun W, Chen Y, He M, Yue J, et al. Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy. Signal Transduct Target Ther. 2019;4:4 pubmed publisher
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| Zhang R, Varela M, Vallentgoed W, Forn Cuni G, van der Vaart M, Meijer A. The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection. PLoS Pathog. 2019;15:e1007329 pubmed publisher
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| Senturk M, Lin G, Zuo Z, Mao D, Watson E, Mikos A, et al. Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol. 2019;21:384-396 pubmed publisher
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| Horos R, Büscher M, Kleinendorst R, Alleaume A, Tarafder A, Schwarzl T, et al. The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy. Cell. 2019;176:1054-1067.e12 pubmed publisher
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| Xia Y, Liu N, Xie X, Bi G, Ba H, Li L, et al. The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion. Autophagy. 2019;15:960-975 pubmed publisher
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| Sil S, Niu F, Tom E, Liao K, Periyasamy P, Buch S. Cocaine Mediated Neuroinflammation: Role of Dysregulated Autophagy in Pericytes. Mol Neurobiol. 2019;56:3576-3590 pubmed publisher
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| Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, et al. Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. J Cell Biol. 2018;217:3817-3828 pubmed publisher
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| Chen B, Zheng Y, Zhang J. Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. Front Endocrinol (Lausanne). 2018;9:366 pubmed publisher
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| Lin X, Cui M, Xu D, Hong D, Xia Y, Xu C, et al. Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy. Cell Death Dis. 2018;9:768 pubmed publisher
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| Thangaraj A, Periyasamy P, Liao K, Bendi V, Callen S, Pendyala G, et al. HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. Autophagy. 2018;14:1596-1619 pubmed publisher
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| Matsumoto G, Inobe T, Amano T, Murai K, Nukina N, Mori N. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Sci Rep. 2018;8:9585 pubmed publisher
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| Park S, Lim J, Ramakrishina S, Kim S, Kim W, Lee J, et al. Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination. Neuron. 2018;99:83-97.e7 pubmed publisher
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| Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018;217:2633-2645 pubmed publisher
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| Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher
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| Shen X, Kan S, Hu J, Li M, Lu G, Zhang M, et al. EMC6/TMEM93 suppresses glioblastoma proliferation by modulating autophagy. Cell Death Dis. 2016;7:e2043 pubmed publisher
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| Song P, Li S, Wu H, Gao R, Rao G, Wang D, et al. Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. Protein Cell. 2016;7:114-29 pubmed publisher
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| Sanchez A, Varano G, de Rozieres C, Maung R, Catalan I, Dowling C, et al. Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage. Antimicrob Agents Chemother. 2016;60:168-79 pubmed publisher
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