product summary
company name :
MBL International
product type :
antibody
product name :
Anti-Atg16L (Human) pAb
catalog :
PM040
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation
more info or order :
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 7A
Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed publisher
  • western blot knockout validation; human; 1:1000; fig 7
Bento C, Ashkenazi A, Jimenez Sanchez M, Rubinsztein D. The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun. 2016;7:11803 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 6c
  • western blot; human; 1:1000; loading ...; fig 6a
Boukhalfa A, Nascimbeni A, Ramel D, Dupont N, Hirsch E, Gayral S, et al. PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress. Nat Commun. 2020;11:294 pubmed publisher
  • immunoprecipitation; human; loading ...; fig s5e
Xu Y, Zhou P, Cheng S, Lu Q, Nowak K, Hopp A, et al. A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy. Cell. 2019;178:552-566.e20 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2d
Ding X, Jiang X, Tian R, Zhao P, Li L, Wang X, et al. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy. 2019;:1-13 pubmed publisher
  • western blot; human; loading ...; fig s3d
Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma J, Tanaka S, et al. Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response. MBio. 2018;9: pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 1a, 1c
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 1b
Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh J, et al. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018;37: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Button R, Roberts S, Willis T, Hanemann C, Luo S. Accumulation of autophagosomes confers cytotoxicity. J Biol Chem. 2017;292:13599-13614 pubmed publisher
  • immunoprecipitation; human; fig s4a
  • western blot; human; fig s2j
Ribeiro C, Sarrami Forooshani R, Setiawan L, Zijlstra Willems E, van Hamme J, Tigchelaar W, et al. Receptor usage dictates HIV-1 restriction by human TRIM5? in dendritic cell subsets. Nature. 2016;540:448-452 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 3
Karanasios E, Walker S, Okkenhaug H, Manifava M, Hummel E, Zimmermann H, et al. Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles. Nat Commun. 2016;7:12420 pubmed publisher
  • western blot; human; 1:1000; fig 1
Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies F, et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun. 2016;7:10533 pubmed publisher
Jia J, Claude Taupin A, Gu Y, Choi S, Peters R, Bissa B, et al. Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal. Dev Cell. 2019;: pubmed publisher
Tamura N, Kageyama S, Komatsu M, Waguri S. Hyperosmotic stress induces unconventional autophagy independent of the Ulk1 complex. Mol Cell Biol. 2019;: pubmed publisher
Dudley L, Cabodevilla A, Makar A, Sztacho M, Michelberger T, Marsh J, et al. Intrinsic lipid binding activity of ATG16L1 supports efficient membrane anchoring and autophagy. EMBO J. 2019;38: pubmed publisher
Mehto S, Jena K, Nath P, Chauhan S, Kolapalli S, Das S, et al. The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. Mol Cell. 2019;73:429-445.e7 pubmed publisher
McCaughey J, Stevenson N, Cross S, Stephens D. ER-to-Golgi trafficking of procollagen in the absence of large carriers. J Cell Biol. 2019;218:929-948 pubmed publisher
Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma J, Tanaka S, et al. Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells. Front Immunol. 2018;9:2073 pubmed publisher
Puri C, Vicinanza M, Ashkenazi A, Gratian M, Zhang Q, Bento C, et al. The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A. Dev Cell. 2018;45:114-131.e8 pubmed publisher
Wallot Hieke N, Verma N, Schlütermann D, Berleth N, Deitersen J, Böhler P, et al. Systematic analysis of ATG13 domain requirements for autophagy induction. Autophagy. 2018;14:743-763 pubmed publisher
Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, et al. Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Autophagy. 2017;13:1145-1160 pubmed publisher
company information
MBL International
15A Constitution Way Woburn, MA 01801
customerservice@mblintl.com
http://www.mblintl.com
headquarters: United States