protein

Human TNFSF18 / GITRL Protein (Recombinant) - LS-G27171

LS-G27171

LS-G27171

Human TNFSF18 / GITRL Protein (Recombinant) - LS-G27171

Activation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF). AITRL is a Type II single transmembrane protein and shares low conservation within the extracellular domain with other TNFSF members. AITRL is expressed on macrophages, immature and mature dendritic cells and B cells. Its receptor, Activation-Inducible TNFR family Receptor (AITR), is expressed on T lymphocytes, natural killer (NK) cells, and antigen-presenting cells. Upon binding by AITRL, AITR can be released. AITR activation increases resistance to tumors and viral infections and is involved in autoimmune and inflammatory processes. In addition, activated AITR increases TCR-induced T cell proliferation and cytokine production and rescues T cells and NK cells from apoptosis. Recombinant human Activation-Inducible TNF-Related Ligand (rhAITRL) produced in E. coli is a single non-glycosylated polypeptide chain containing 126 amino acids. A fully biologically active molecule, rhAITRL has a molecular mass of 14.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.

Lyophilized from 50 mM Tris, pH 8.0

Recombinant

Human

E. coli

Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 2 weeks or at -20°c for up to 3 months.

Greater than 95% by SDS-PAGE

14.3 kDa (SDS-PAGE)

TNFSF18 / GITRL

TNFSF18

TNF

TNFSF18, AITR ligand, AITRL, GITR ligand, GITRL, HGITRL, TL6

Worldwide