This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
protein
product name :
Human CXCL11 Protein (Recombinant) - LS-G27147
catalog :
LS-G27147
product information
ProteinId :
27147
CatalogNumber :
LS-G27147
Product Name :
Human CXCL11 Protein (Recombinant) - LS-G27147
Description :
I-TAC (Interferon-inducible T-cell a Chemoattractant), also known as CXCL11, is a chemokine belonging to the CXCL subfamily. Along with Interferon-gamma induced Protein 10 kDa and Monokine Induced by Interferon-gamma , I-TAC is strongly up-regulated by Interferon-gamma and binds to the G-protein coupled receptor CXCR3. The expression of CXCR3 is associated with Th1-mediated immune responses and mediates chemotaxis of Th1 cells. I-TAC induces, maintains, and amplifies the inflammatory reactions, and sustains chronic immune responses against self-antigens. Although CXCR3 was thought to be the exclusive receptor of I-TAC initially, more evidence has shown that I-TAC can also bind to CXCR4 and CXCR7, and that I-TAC plays important roles in tumor development and angiostasis. Recombinant human I-TAC/CXCL11 (rhI-TAC) produced in E. coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-TAC has a molecular mass of 8.4 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
PresentationDesc :
Lyophilized from PBS
ProteinType :
Recombinant
ProteinSpecies :
Human
ProteinSourceSpecies :
E. coli
RecommendedStorage :
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 2 weeks or at -20°c for up to 3 months.
Purification :
Greater than 95% by SDS-PAGE and HPLC
PredictedMolecularWeight :
8.4 kDa (SDS-PAGE)
Gene :
CXCL11
StandardGeneSymbol :
CXCL11
Subfamily :
Intercrine alpha
gene family :
Intercrine
Synonyms :
CXCL11, Beta-R1, Chemokine h174, Chemokine ip-9, Chemokine itac, H174, I-TAC, IP9, ITAC, IP-9, SCYB11, Small inducible cytokine B11, B-R1, C-X-C motif chemokine 11, SCYB9B, Small-inducible cytokine B11
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.